Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/7207
Title: | The immune system in Parkinson's disease: what we know so far | Authors: | Roodveldt, Cintia Bernardino, Liliana Oztop-Cakmak, Ozgur Dragić, Milorad Fladmark, Kari Espolin Ertan, Sibel Busra, Aktas Pita, Carlos Ciglar, Lucia Garraux, Gaetan Williams-Gray, Caroline Pacheco, Rodrigo Romero-Ramos, Marina |
Keywords: | B cells;T cells;alpha-synuclein;microglia;monocytes | Issue Date: | 4-Jun-2024 | Rank: | M21a | Publisher: | Oxford University Press | Journal: | Brain : a journal of neurology | Abstract: | Parkinson's disease (PD) is characterised neuropathologically by the degeneration of dopaminergic neurons in the ventral midbrain, the accumulation of α-synuclein (α-syn) aggregates in neurons, and chronic neuroinflammation. In the past two decades, in vitro, ex vivo and in vivo studies have consistently shown the involvement of inflammatory responses mediated by microglia and astrocytes, which may be elicited by pathological α-syn or signals from affected neurons and other cell types, and are directly linked to neurodegeneration and disease development. Besides the prominent immune alterations seen in the central nervous system (CNS), including the infiltration of T-cells into the brain, more recent studies have demonstrated important changes in the peripheral immune profile within both the innate and adaptive compartments, particularly involving monocytes, CD4+ and CD8+ T-cells. This review aims to integrate the consolidated understanding of immune-related processes underlying the pathogenesis of PD, focusing on both central and peripheral immune cells, neuron-glia crosstalk as well as the central-peripheral immune interaction during the development of PD. Our analysis seeks to provide a comprehensive view of the emerging knowledge of the mechanisms of immunity in PD and the implications of this for better understanding the overall pathogenesis of this disease. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/7207 | ISSN: | 0006-8950 1460-2156 |
DOI: | 10.1093/brain/awae177 |
Appears in Collections: | Journal Article |
Show full item record
SCOPUSTM
Citations
2
checked on Dec 5, 2024
Page view(s)
8
checked on Dec 6, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.