Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7207
Title: The immune system in Parkinson's disease: what we know so far
Authors: Roodveldt, Cintia
Bernardino, Liliana
Oztop-Cakmak, Ozgur
Dragić, Milorad 
Fladmark, Kari Espolin
Ertan, Sibel
Busra, Aktas
Pita, Carlos
Ciglar, Lucia
Garraux, Gaetan
Williams-Gray, Caroline
Pacheco, Rodrigo
Romero-Ramos, Marina
Keywords: B cells;T cells;alpha-synuclein;microglia;monocytes
Issue Date: 4-Jun-2024
Rank: M21a
Publisher: Oxford University Press
Journal: Brain : a journal of neurology
Abstract: 
Parkinson's disease (PD) is characterised neuropathologically by the degeneration of dopaminergic neurons in the ventral midbrain, the accumulation of α-synuclein (α-syn) aggregates in neurons, and chronic neuroinflammation. In the past two decades, in vitro, ex vivo and in vivo studies have consistently shown the involvement of inflammatory responses mediated by microglia and astrocytes, which may be elicited by pathological α-syn or signals from affected neurons and other cell types, and are directly linked to neurodegeneration and disease development. Besides the prominent immune alterations seen in the central nervous system (CNS), including the infiltration of T-cells into the brain, more recent studies have demonstrated important changes in the peripheral immune profile within both the innate and adaptive compartments, particularly involving monocytes, CD4+ and CD8+ T-cells. This review aims to integrate the consolidated understanding of immune-related processes underlying the pathogenesis of PD, focusing on both central and peripheral immune cells, neuron-glia crosstalk as well as the central-peripheral immune interaction during the development of PD. Our analysis seeks to provide a comprehensive view of the emerging knowledge of the mechanisms of immunity in PD and the implications of this for better understanding the overall pathogenesis of this disease.
URI: https://biore.bio.bg.ac.rs/handle/123456789/7207
ISSN: 0006-8950
1460-2156
DOI: 10.1093/brain/awae177
Appears in Collections:Journal Article

Show full item record

SCOPUSTM   
Citations

2
checked on Dec 5, 2024

Page view(s)

8
checked on Dec 6, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.