Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7190
Title: Exploring In Vitro Immunomodulatory Properties of Moss Atrichum undulatum Extracts
Authors: Lunić, Tanja 
Rakić, Marija
Sabovljević, Aneta 
Sabovljević, Marko 
Filipović, Tamara
Božić, Bojan 
Božić Nedeljković, Biljana 
Keywords: Axenic mosses;;Atrichum undulatum;;Microglia;;Neuroinflammation;;Immunomodulation.
Issue Date: 2024
Rank: M21
Publisher: MPDI
Journal: Plants
Volume: 13
Issue: 10
Start page: 1349
Abstract: 
Bryophytes are rich sources of diverse secondary metabolites with a wide range of biological activities, including anti-inflammatory, antitumor and antimicrobial effects. The aim of this study was to investigate the chemical composition of extracts from two different genotypes (Serbian and Hungarian) of the axenic moss Atrichum undulatum and evaluate the immunomodulatory potential of the prepared extracts in vitro. Both genotypes of moss samples were cultivated in vitro and subsequently extracted in a Soxhlet apparatus with methanol or ethyl acetate. The highest concentration of total phenolic compounds was found in the methanolic extract of the Serbian genotype (54.25 mg GAE/g extract), while the ethyl acetate extract of the Hungarian genotype showed the highest concentration of phenolic acids (163.20 mg CAE/extract), flavonoids (35.57 mg QE/extract), and flavonols (2.25 mg QE/extract). The extracts showed anti-neuroinflammatory properties by reducing the production of reactive oxygen species, nitric oxide, and tumor necrosis factor alpha by lipopolysaccharide-stimulated microglial cells. Moreover, they mitigated the cytotoxic effects of the pro-inflammatory mediators produced by activated microglia on neurons. The data obtained suggest that extracts from A. undulatum moss have promising anti-neuroinflammatory and neuroprotective properties, making them interesting candidates for further research to combat neuroinflammation.
URI: https://biore.bio.bg.ac.rs/handle/123456789/7190
ISSN: 2223-7747
DOI: 10.3390/plants13101349
Appears in Collections:Journal Article

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