Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/71
Title: Time-dependent effects of starvation on serum, pituitary and hypothalamic leptin levels in rats
Authors: Vujović, Predrag 
Lakić, Iva 
Laketa, Danijela 
Jasnić, Nebojša 
Đurašević, Siniša 
Cvijić, Gordana
Đorđević, Jelena 
Keywords: Hypothalamus;Leptin;Pituitary;Rat;Starvation
Issue Date: 1-Dec-2011
Journal: Physiological Research
Abstract: 
Leptin is produced by white adipose tissue and other cell types and is involved in both short- and long-term appetite control. Here we studied effects of starvation on serum, pituitary and hypothalamic levels of leptin during 72 h period. Each of the starved groups was sacrificed simultaneously with the group of ad libitum fed animals. The progression of the discrete starvation response phases was monitored by testing the blood glucose, free fatty acid, urea and corticosterone levels. Starvation caused biphasic increase in corticosterone and free fatty acid levels, and significant but transient decrease in urea and glucose levels. Starvation also abolished diurnal rhythm of changes in leptin concentrations in serum and hypothalamic and pituitary tissues. Only 6 h starving period was sufficient to lock serum leptin at low levels, whereas 12 h were needed to silence leptin production/ secretion in hypothalamus for the whole examined period. In contrast, leptin production by pituitary tissues of starved animals required 24 h to reach minimum, followed by full recovery by the end of starvation period. These results indicate the tissue specific pattern of leptin release and suggest that the locally produced leptin could activate its receptor in pituitary cells independently of serum levels of this hormone.
URI: https://biore.bio.bg.ac.rs/handle/123456789/71
ISSN: 0862-8408
Appears in Collections:Journal Article

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