Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7097
Title: Dominant lignan profiles and antidiabetic activity of thermally treated and non-treated burdock seeds
Authors: Pljevljakušić, Dejan
Živković, Jelena
Petričević, Saša
Alimpić Aradski, Ana 
Radan, Milica
Šavikin, Katarina
Ristić, Slavica
Keywords: Burdock;;Seed;;Lignan;;in vivo;;in vitro;;Diabetes;;Metabolic syndrome.
Issue Date: 2024
Rank: M21a
Publisher: Elsevier
Journal: Industrial Crops and Products
Volume: 211
Start page: 118206
Abstract: 
Burdock seeds (Fructus arctii) are used as a traditional medicine for cough, inflammation, detoxification, cancer and diabetes, usually as decoction obtained with seeds subjected to thermal pre-treatment. The present work aimed to perform the phytochemical characterization of the stir-baked and non-baked seeds of various Arctium lappa populations from nine localities. Arctiin was dominant compound in non-baked seeds ranging from 40.6–92.6 mg/g. Thermal treatment resulted in a significant transformation of phenolic compounds and arctigenin was prevalent in the baked samples with the content from 25.2–57.4 mg/g. The antidiabetic potential of baked and non-baked burdock seed extracts was further evaluated in vitro by inhibition of α-amylase and α-glucosidase activity, while molecular docking analysis was used to reveal the main molecular interactions underlying the inhibitory effects on these enzymes. In vitro study showed that stir-baked burdock seed extracts were stronger inhibitors of both enzymes compared to non-baked. The several extracts showed strong inhibition of both enzymes by almost or more than 60%, which was lower compared to acarbose (82.99% at a concentration of 1 mg/mL). Arctin and arctigenin were individually significantly stronger inhibitors of α-amylase and particularly α-glucosidase compared to burdock extracts and acarbose, and their activity was concentration dependent. Moreover, antidiabetic activity for the most active sample was determined in vivo using animals on high-fat and sucrose diet, where promising results were obtained. Briefly, after three months of administration of the stir-baked seed extract (100 mg/kg body weight), complete recovery from a hyperglycemic state was achieved. According to the obtained results A. lappa stir-baked seed extract is a potential drug with hypoglycemic action as indicated by in vitro, in vivo and in silico studies.
URI: https://biore.bio.bg.ac.rs/handle/123456789/7097
ISSN: 09266690
DOI: 10.1016/j.indcrop.2024.118206
Appears in Collections:Journal Article

Show full item record

Page view(s)

5
checked on Nov 4, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.