Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7091
Title: Metabolic remodeling of visceral and subcutaneous white adipose tissue during reacclimation of rats after cold
Authors: Marta Budnar Soskic, Marta
Zakic, Tamara
Korać, Aleksandra 
Korać, Bato 
Jankovic, Aleksandra
Issue Date: 19-Jan-2024
Rank: M22
Publisher: International Association for the Philosophy of Sport/Human Kinetics
Journal: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
Abstract: 
Deciphering lipid metabolism in white adipose tissue (WAT) depots during weight gain is important to understand the heterogeneity of WAT and its roles in obesity. Here, we examined the expression of key enzymes of lipid metabolism and changes in the morphology of representative visceral (epididymal) and subcutaneous (inguinal) WAT (eWAT and iWAT, respectively) - in adult male rats acclimated to cold (4±1 °C) for 45 days and reacclimated to room temperature (RT, 22±1 °C) for 1, 3, 7, 12, 21, or 45 days. The relative mass of both depots decreased to a similar extent after cold acclimation. However, fatty acid synthase (FAS), glucose-6-phosphate dehydrogenase (G6PDH), and medium-chain acyl-CoA dehydrogenase (ACADM) protein level increased only in eWAT, whereas adipose triglyceride lipase (ATGL) expression increased only in iWAT. During reacclimation, the relative mass of eWAT reached control values on day 12 and that of iWAT on day 45 of reacclimation. The faster recovery of eWAT mass is associated with higher expression of FAS, acetyl-CoA carboxylase (ACC), G6PDH, and ACADM during reacclimation and a delayed increase in ATGL. The absence of an increase in proliferating cell nuclear antigen suggests that the observed depot-specific mass increase is predominantly due to metabolic adjustments. In summary, this study shows a differential rate of visceral and subcutaneous adipose tissue weight regain during post-cold reacclimation of rats at RT. Faster recovery of the visceral WAT as compared to subcutaneous WAT during reacclimation at RT could be attributed to observed differences in the expression patterns of lipid metabolic enzymes.
URI: https://biore.bio.bg.ac.rs/handle/123456789/7091
ISSN: 1715-5312
1715-5320
DOI: 10.1139/apnm-2023-0448
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