Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7012
Title: Redox and metabolic reprogramming in breast cancer and cancer-associated adipose tissue
Authors: Zakic, Tamara
Pekovic-Vaughan, Vanja
Čvoro, Aleksandra 
Korać, Aleksandra 
Jankovic, Aleksandra
Korać, Bato 
Keywords: adipose tissue;breast cancer;circadian rhythms;estrogen;redox-metabolic reprogramming;tumor microenvironment
Issue Date: 23-Dec-2023
Rank: M21
Publisher: Elsevier BV
Journal: FEBS letters
Abstract: 
Redox and metabolic processes are tightly coupled in both physiological and pathological conditions. In cancer, their integration occurs at multiple levels and is characterized by synchronized reprogramming both in the tumor tissue and its specific but heterogeneous microenvironment. In breast cancer, the principal microenvironment is the cancer-associated adipose tissue (CAAT). Understanding how the redox-metabolic reprogramming becomes coordinated in human breast cancer is imperative both for cancer prevention and for the establishment of new therapeutic approaches. This review aims to provide an overview of the current knowledge of the redox profiles and regulation of intermediary metabolism in breast cancer while considering the tumor and CAAT of breast cancer as a unique Warburg's pseudo-organ. As cancer is now recognized as a systemic metabolic disease, we have paid particular attention to the cell-specific redox-metabolic reprogramming and the roles of estrogen receptors and circadian rhythms, as well as their crosstalk in the development, growth, progression, and prognosis of breast cancer.
URI: https://biore.bio.bg.ac.rs/handle/123456789/7012
ISSN: 00145793
DOI: 10.1002/1873-3468.14794
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