Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/6446
Title: In vitro antifungal and demelanizing activity of Nepeta rtanjensis essential oil against the human pathogen Bipolaris spicifera
Authors: Ljaljević-Grbić, Milica 
Stupar, Miloš 
Vukojević, Jelena 
Grubišić, D.
Keywords: Bipolaris spicifera (Bainier) Subram.;;Essential oil;;Antifungal activity;;Melanin;;Human pathogens;;Depigmentation.
Issue Date: 2011
Rank: M23
Publisher: Srpsko biološko društvo i grupa naučnih instituta
Journal: Archives of Biological Science
Volume: 63
Issue: 3
Start page: 897
End page: 905
Abstract: 
The antifungal activity of Nepeta rtanjensis Diklić & Milojević essential oil was tested against the human pathogenic fungus Bipolaris spicifera (Bainier) Subramanian via mycelial growth assay and conidia germination assay. The minimally inhibitory concentration (MIC) of the oil was determined at 1.0 μg ml-1, while the MIC for the antifungal drug Bifonazole in a positive control was determined at 10.0 μg ml-1. The maximum of conidia germination inhibition was accomplished at 0.6 μg ml-1. In addition, at 0.6 μg ml-1 and 0.8 μg ml-1 the oil was able to cause morphophysiological changes in B. spicifera. The most significant result is the bleaching effect of the melanized conidial apparatus of the test fungi, since the melanin is the virulence factor in human pathogenic fungi. These results showed the strong antifungal properties of N. rtanjensis essential oil, supporting its possible rational use as an alternative source of new antifungal compounds.
URI: https://biore.bio.bg.ac.rs/handle/123456789/6446
DOI: 10.2298/ABS1103897G
Appears in Collections:Journal Article

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