Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/6330
Title: Poly(methacrylic acid) hydrogels crosslinked by poly(ethylene glycol) diacrylate as pH-responsive systems for drug delivery applications
Authors: Ugrinović, Vukašin
Marković, Maja
Božić, Bojan 
Panić, Vesna
Veljović, Đorđe
Keywords: Smart materials;;Colon-specific delivery;;Ciprofloxacin;;Oxaprozin.
Issue Date: 2023
Rank: M23
Publisher: Savez hemijskih inženjera
Journal: Hemijska industrija
Abstract: 
Hydrogels are attractive materials for drug delivery applications due to biocompatible, porous
structure with the possibility to load and deliver drugs in a controllable manner. In this paper,
poly(methacrylic acid) (PMAA) hydrogels are described, which are synthesized by free-radical
polymerization, using poly(ethylene glycol) diacrylate (PEGDA) as a crosslinker. Influence of the
PEGDA content on hydrogel properties was investigated and compared to commonly used
crosslinker - N,N’-methylenebisacrylamide (MBA). The increasing concentration of crosslinkers
led to a higher degree of crosslinking, which was demonstrated by a higher degree of
conversion, lower swelling capacity, and improved thermal stability and mechanical properties.
Also, the PEGDA-crosslinked hydrogels demonstrated a higher degree of crosslinking than the
corresponding MBA-crosslinked hydrogels. Potential application of the synthesized hydrogels
for controlled drug delivery was investigated by using two model drugs - oxaprozin and
ciprofloxacin. In vitro drug release tests indicated that the interactions between drug, polymer
and medium have a key influence on the drug release behavior, rather than the swelling rate.
Drug release tests in simulated gastrointestinal conditions indicated that PEGDA-crosslinked
PMAA hydrogels are suitable for colon-targeted delivery of oxaprozin.
URI: https://biore.bio.bg.ac.rs/handle/123456789/6330
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