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https://biore.bio.bg.ac.rs/handle/123456789/6236| Title: | Defining the ferroptotic phenotype of beta cells in type 1 diabetes and its inhibition as a potential antidiabetic strategy | Authors: | Markelić, Milica Stancic, Ana Saksida, Tamara Grigorov, Ilijana Micanovic, Dragica Veličković, Ksenija Martinovic, Vesna Savic, Nevena Gudelj, Andjelija Otasevic, Vesna |
Keywords: | diabetes;ferroptosis;ferroptosis inhibitor;ferrostatin-1;β-cell death | Issue Date: | 3-Aug-2023 | Rank: | M21 | Publisher: | Frontiers | Project: | Serbian Science and Diaspora Collaboration Program: Knowledge Exchange Vouchers “Ferroptosis in the β-cells death: a possible strategy for diabetes treatment”, acronym: BetFeSis - Science Fund of the Republic of Serbia Project of the Ministry of Science, Technological Development and Innovation of Republic of Serbia |
Journal: | Frontiers in Endocrinology | Volume: | 14 | Start page: | 1227498 | Abstract: | Recently, the involvement of ferroptotic cell death in the reduction of β-cell mass in diabetes has been demonstrated. To elucidate the mechanisms of β-cell ferroptosis and potential antidiabetic effects of the ferroptosis inhibitor ferrostatin-1 (Fer-1) in vivo, a mouse model of type 1 diabetes (T1D) was used. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/6236 | ISSN: | 1664-2392 | DOI: | 10.3389/fendo.2023.1227498 |
| Appears in Collections: | Journal Article |
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