Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/6119
Title: Age‑related changes in antioxidant defenses of the Mediterranean centipede Scolopendra cingulata (Chilopoda)
Authors: Mitić, Bojan 
Borković-Mitić, Slavica
Vranković, Jelena
Stojanović, Dalibor 
Pavlović, Slađan
Keywords: Age-related changes;;Antioxidant defenses;;Scolopendra cingulata;;Chilopoda
Issue Date: 9-Mar-2023
Rank: M23
Publisher: Springer
Journal: Journal of Comparative Physiology. B: Biochemical, Systemic, and Environmental Physiology
Volume: 193
Issue: 3
Start page: 249
End page: 260
Abstract: 
The activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), and glutathione S-transferase (GST), as well as the concentrations of sulfhydryl (SH) groups and glutathione (GSH) were analyzed in five age classes of the Mediterranean centipede Scolopendra cingulata as follows: embryo, adolescens, maturus junior, maturus, and maturus senior. The data obtained showed the presence of SOD, CAT, GSH-Px, GR, GST, and SH groups in embryos. The transition from embryo to adolescens was accompanied by an increase in the activities of all studied enzymes, in response to the increased production of ROS due to the increased metabolic activity of the centipede associated with growth and development. Our results show that trends in antioxidant enzyme (AOE) activities were not uniform among adult age classes, suggesting that maturus junior, maturus, and maturus senior differentially respond and/or have different susceptibility to ROS. On the other hand, GSH concentration in embryos was undetectable, highest in adolescens and decreased in the latter part of life. Pearson correlation analysis in embryos showed that the activities of the AOEs were strongly and positively correlated with each other but negatively correlated with GSH and SH groups. At later age classes, SOD, CAT, GSH-Px, GR, GSH, and SH groups were no longer significantly correlated with GST. In the discriminant analysis, the variables that separated the age classes were GR, GST, SH groups, and body length. Body length was directly related to the age of individuals, clearly indicating that development/aging affects the regulation of antioxidant defense in this species.
URI: https://biore.bio.bg.ac.rs/handle/123456789/6119
DOI: 10.1007/s00360-023-01481-w
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