Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/5493
Title: Aspergilli Response to Benzalkonium Chloride and Novel-Synthesized Fullerenol/Benzalkonium Chloride Nanocomposite
Authors: Unković, Nikola 
Ljaljević-Grbić, Milica 
Stupar, Miloš 
Vukojević, Jelena 
Janković, Vesna
Jović, Danica
Đorđević, Aleksandar
Issue Date: 29-Jul-2015
Rank: M21
Publisher: ScientificWorld Ltd.
Journal: Scientific World Journal
Abstract: 
A comprehensive comparative analysis of antifungal potential of benzalkonium chloride and newly synthesized fullerenol/benzalkonium chloride nanocomposite was conducted to assess the possible impact of carbon-based nanocarrier on antimicrobial properties of the commonly used biocide. Physical characterization of synthesized nanocomposite showed zeta potential of +37.4 mV and inhomogeneous particles size distribution, with nanocomposite particles’ dimensions within 30–143 nm and maximum number of particles at 44 nm. The effect of pure and fullerenol nanocarrier-bound biocide was evaluated in eight Aspergillus species. In mycelial growth assay, nanocomposite was more potent, as fungicidal effect of 1.04/0.6 μg mL−1 was obtained in all but one of the isolates (A. niger), while proportional concentration of pure biocide (0.6 μg mL−1) completely inhibited mycelial growth of only three Aspergillus species. However, conidia appear to be less susceptible to nanocomposite treatment, as lower fungistatic (MIC) and fungicidal (MFC) concentrations were obtained with biocide alone (MIC in range from 0.03 to 0.15 μg mL−1 and MFC from 0.075 to 0.45 μg mL−1). To a different degree, both substances stimulated aflatoxin B1 production and inhibited ochratoxin A synthesis. Very low mycelium biomass yield, in range from 1.0 to 3.0 mg dry weight, was documented in both biocide and nanocomposite enriched medium.
URI: https://biore.bio.bg.ac.rs/handle/123456789/5493
ISSN: 1537-744X
DOI: 10.1155/2015/109262
Appears in Collections:Journal Article

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