Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/5412
Title: Orally administrated Lactiplantibacillus plantarum BGAN8-derived EPS-AN8 ameliorates Cd hazards in rats
Authors: Brdarić, Emilija
Popović, Dušanka
Soković Bajić, Svetlana
Tucović, Dina
Mutić, Jelena
Čakić-Milošević, Maja 
Đurđić, Slađana
Tolinački, Maja
Popov Aleksandrov, Aleksandra
Golić, Nataša
Mirkov, Ivana
Živković, Milica
Keywords: Cadmium;Exopolysaccharides;Sequestration;Inflammation;Oxidative stress;Microbiota
Issue Date: 2-Feb-2023
Rank: M21
Publisher: MDPI
Journal: International Journal of Molecular Sciences
Volume: 24
Issue: 3
Start page: 2845
Abstract: 
Cadmium (Cd) is a highly toxic metal that is distributed worldwide. Exposure to it is correlated with a vast number of diseases and organism malfunctions. Exopolysaccharides (EPS) derived from Lactiplantibacillus plantarum BGAN8, EPS-AN8, previously showed great potential for the in vitro protection of intestinal cells from this metal. Here, we investigated the potential of food supplemented with EPS-AN8 to protect rats from the hazardous effects of Cd exposure. After thirty days of exposure to lower (5 ppm) and higher (50 ppm)-Cd doses, the administration of EPS-AN8 led to decreased Cd content in the kidneys, liver, and blood compared to only Cd-treated groups, whereas the fecal Cd content was strongly enriched. In addition, EPS-AN8 reversed Cd-provoked effects on the most significant parameters of oxidative stress (MDA, CAT, GST, and GSH) and inflammation (IL-1β, TNF-α, and IFN-γ) in the duodenum. Moreover, micrographs of the duodenum were in line with these findings. As the gut microbiota has an important role in maintaining homeostasis, we used 16S rRNA amplicon sequencing and investigated the effects of Cd and EPS-AN8 on one part of the microbiota presented in the duodenum. Although Cd decreased the growth of lactobacilli and mostly favored the blooming of opportunistic pathogen bacteria, parallel intake of EPS-AN8 reversed those changes. Therefore, our results imply that EPS-AN8 might be extremely noteworthy in combatting this toxic environmental pollutant.
URI: https://biore.bio.bg.ac.rs/handle/123456789/5412
ISSN: 1422-0067
DOI: 10.3390/ijms24032845
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