Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/5360
Title: | MiR-375 and miR-21 as Potential Biomarkers of Prostate Cancer: Comparison of Matching Samples of Plasma and Exosomes | Authors: | Matijašević, Suzana Dobrijević, Zorana Kotarac, Nevena Filipović, Lidija Popović, Milica Korać, Aleksandra Vuković, Ivan Savić-Pavićević, Dušanka Brajušković, Goran |
Keywords: | Prostate cancer;Exosomes;Plasma;microRNAs;miR-21;miR-375 | Issue Date: | 9-Dec-2022 | Rank: | M22 | Publisher: | MDPI | Journal: | Genes | Volume: | 13 | Issue: | 12 | Start page: | 2320 | Abstract: | MiR-21 and miR-375 have been reported as dysregulated in prostate cancer (PCa) in multiple previous studies. Still, variable or even opposing data for the expression of these microRNAs in PCa were found, and their potential biomarker properties remain elusive. In an attempt to clarify their significance as PCa biomarkers, as well as to compare different types of specimens as a source of relevant microRNAs, we used plasma and matching plasma-derived exosomes from patients with PCa and patients with benign prostatic hyperplasia (BPH). Plasma and exosomes were obtained from 34 patients with PCa and 34 patients with BPH, and their levels of expression of miR-21 and miR-375 were determined by RT-qPCR. We found no significant difference in the level of expression of these microRNAs in plasma and exosomes between patients with PCa and BPH. The level of exosomal miR-21 was elevated in PCa patients with high serum PSA values, as well as in patients with aggressive PCa, while for plasma samples, the results remained insignificant. For miR-375, we did not find an association with the values of standard prognostic parameters of PCa, nor with cancer aggressiveness. Therefore, our results support the potential prognostic role of exosomal miR-21 expression levels in PCa. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/5360 | ISSN: | 2073-4425 | DOI: | 10.3390/genes13122320 |
Appears in Collections: | Journal Article |
Show full item record
SCOPUSTM
Citations
12
checked on Dec 17, 2024
Page view(s)
15
checked on Dec 23, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.