Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/5360
Title: MiR-375 and miR-21 as Potential Biomarkers of Prostate Cancer: Comparison of Matching Samples of Plasma and Exosomes
Authors: Matijašević, Suzana 
Dobrijević, Zorana
Kotarac, Nevena 
Filipović, Lidija
Popović, Milica
Korać, Aleksandra 
Vuković, Ivan
Savić-Pavićević, Dušanka 
Brajušković, Goran 
Keywords: Prostate cancer;Exosomes;Plasma;microRNAs;miR-21;miR-375
Issue Date: 9-Dec-2022
Rank: M22
Publisher: MDPI
Journal: Genes
Volume: 13
Issue: 12
Start page: 2320
Abstract: 
MiR-21 and miR-375 have been reported as dysregulated in prostate cancer (PCa) in multiple previous studies. Still, variable or even opposing data for the expression of these microRNAs in PCa were found, and their potential biomarker properties remain elusive. In an attempt to clarify their significance as PCa biomarkers, as well as to compare different types of specimens as a source of relevant microRNAs, we used plasma and matching plasma-derived exosomes from patients with PCa and patients with benign prostatic hyperplasia (BPH). Plasma and exosomes were obtained from 34 patients with PCa and 34 patients with BPH, and their levels of expression of miR-21 and miR-375 were determined by RT-qPCR. We found no significant difference in the level of expression of these microRNAs in plasma and exosomes between patients with PCa and BPH. The level of exosomal miR-21 was elevated in PCa patients with high serum PSA values, as well as in patients with aggressive PCa, while for plasma samples, the results remained insignificant. For miR-375, we did not find an association with the values of standard prognostic parameters of PCa, nor with cancer aggressiveness. Therefore, our results support the potential prognostic role of exosomal miR-21 expression levels in PCa.
URI: https://biore.bio.bg.ac.rs/handle/123456789/5360
ISSN: 2073-4425
DOI: 10.3390/genes13122320
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