Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/5282
Title: Melanoma Cell Reprogramming and Awakening of Antitumor Immunity as a Fingerprint of Hyper-Harmonized Hydroxylated Fullerene Water Complex (3HFWC) and Hyperpolarized Light Application In Vivo
Authors: Markelić, Milica 
Mojić, Marija
Bovan, Dijana
Jelača, Sanja
Jović, Zorana
Purić, Milica
Koruga, Djuro
Mijatović, Sanja
Maksimović-Ivanić, Danijela
Keywords: melanoma;C60 fullerene;hyperpolarized light;Senescence;Differentiation
Issue Date: 17-Jan-2023
Rank: M21
Publisher: MDPI
Project: Ministry of Education, Science and Technological Development of the Republic of Serbia, grant number 451-03-68/2022-14/200007
Zepter International Company, grant number 20/02847
Journal: Nanomaterials
Abstract: 
In our recent study, we showed that in vitro treatment of melanoma cells with hyperpolarized light (HPL) as well as with the second derivative of fullerene, hyper-harmonized hydroxylated fullerene water complex (3HFWC) reduced viability of cells by decreasing their proliferative capacity and inducing senescence and reprogramming towards a normal, melanocytic phenotype. Therefore, we wanted to determine whether these effects persisted in vivo in the syngeneic mouse melanoma model with a combined treatment of HPL irradiation and 3HFWC per os. Our results demonstrated the potent antitumor effects of 3HFWC nanosubstance assisted by HPL irradiation. These effects were primarily driven by the stimulation of melanoma cell growth arrest, the establishment of a senescent phenotype, and melanocytic differentiation on the one hand, and the awakening of the antitumor immune response on the other. In addition, the combined treatment reduced the protumorigenic activity of immune cells by depleting T regulatory cells, myeloid-derived suppressors, and M2 macrophages. The support of the 3HFWC substance by HPL irradiation may be the axis of the new approach design based on tumor cell reprogramming synchronized with the mobilization of the host’s protective immune response.
URI: https://biore.bio.bg.ac.rs/handle/123456789/5282
ISSN: 2079-4991
DOI: 10.3390/nano13030372
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