Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/5282
Title: | Melanoma Cell Reprogramming and Awakening of Antitumor Immunity as a Fingerprint of Hyper-Harmonized Hydroxylated Fullerene Water Complex (3HFWC) and Hyperpolarized Light Application In Vivo | Authors: | Markelić, Milica Mojić, Marija Bovan, Dijana Jelača, Sanja Jović, Zorana Purić, Milica Koruga, Djuro Mijatović, Sanja Maksimović-Ivanić, Danijela |
Keywords: | melanoma;C60 fullerene;hyperpolarized light;Senescence;Differentiation | Issue Date: | 17-Jan-2023 | Rank: | M21 | Publisher: | MDPI | Project: | Ministry of Education, Science and Technological Development of the Republic of Serbia, grant number 451-03-68/2022-14/200007 Zepter International Company, grant number 20/02847 |
Journal: | Nanomaterials | Abstract: | In our recent study, we showed that in vitro treatment of melanoma cells with hyperpolarized light (HPL) as well as with the second derivative of fullerene, hyper-harmonized hydroxylated fullerene water complex (3HFWC) reduced viability of cells by decreasing their proliferative capacity and inducing senescence and reprogramming towards a normal, melanocytic phenotype. Therefore, we wanted to determine whether these effects persisted in vivo in the syngeneic mouse melanoma model with a combined treatment of HPL irradiation and 3HFWC per os. Our results demonstrated the potent antitumor effects of 3HFWC nanosubstance assisted by HPL irradiation. These effects were primarily driven by the stimulation of melanoma cell growth arrest, the establishment of a senescent phenotype, and melanocytic differentiation on the one hand, and the awakening of the antitumor immune response on the other. In addition, the combined treatment reduced the protumorigenic activity of immune cells by depleting T regulatory cells, myeloid-derived suppressors, and M2 macrophages. The support of the 3HFWC substance by HPL irradiation may be the axis of the new approach design based on tumor cell reprogramming synchronized with the mobilization of the host’s protective immune response. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/5282 | ISSN: | 2079-4991 | DOI: | 10.3390/nano13030372 |
Appears in Collections: | Journal Article |
Show full item record
SCOPUSTM
Citations
3
checked on Oct 31, 2024
Page view(s)
3
checked on Nov 4, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.