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Title: | Exploring the antibacterial potential of Lactococcus lactis subsp. lactis bv. diacetylactis BGBU1-4 by genome mining, bacteriocin gene overexpression, and chemical protein synthesis of lactolisterin BU variants |
Authors: | Malešević, Milka Gardijan, Lazar Miljković, Marija M O'Connor, Paula Mirković, Nemanja Jovčić, Branko D Cotter, Paul Jovanović, Goran Kojić, Milan |
Keywords: | Natural breakdown of lactolisterin BU;Genome mining;Bacteriocin overexpression;Chemically synthesized lactolisterin BU;Deletion derivatives of lactolisterin BU |
Issue Date: | 12-Jan-2023 |
Rank: | M23 |
Publisher: | Oxford Academic |
Journal: | Letters in Applied Microbiology |
Abstract: | Lactic acid bacterium Lactococcus lactis BGBU1-4 produces 43 amino acids (aa) long bacteriocin, lactolisterin BU (LBU), a 5.161 kDa peptide with potent antibacterial activity against many Gram-positive pathogens. In addition, BGBU1-4 produces an additional unknown product of 3.642 kDa with antibacterial activity. Here, we determined that the significant amount of naturally produced LBU breaks down... |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/5271 |
DOI: | 10.1093/lambio/ovad004 |
Appears in Collections: | Journal Article |
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