Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/5268
Title: Aquaporin-4 overexpression in rat ALS model
Authors: Nicaise, Charles
Shahnawaz Soyfoo, Muhammad
Authelet, Michèle
De Decker, Robert
Bataveljić, Danijela 
Delporte, Christine
Pochet, Roland
Issue Date: Feb-2009
Rank: M21
Publisher: National Library of Medicine
Journal: Anat Rec (Hoboken).
Volume: 292
Issue: 2
Start page: 207
End page: 213
Abstract: 
Onset of motoneuron death characterizing amyotrophic lateral sclerosis (ALS) is closely linked to modified astrocytic and glial environments. Here, we show that in the spinal cord from transgenic rat overexpressing mutated human SOD1, aquaporin-4 mRNA and protein are specifically overexpressed in the gray matter at end stage of disease. Immunohistochemistry and double immunofluorescence allowed to detect, in the spinal cord gray matter of the ALS rat, increased aquaporin-4 surrounding both vessel and motoneuron perikarya. The use of pre-embedding immunohistochemistry at electron microscopic level confirmed such localization associated with swollen astrocytic processes surrounding the vessels. The AQP4 immunohistochemical labeling surrounding several motoneuron perikarya was only seen in ALS rats. Identification of this AQP4-positive cellular type remains unclear.
URI: https://biore.bio.bg.ac.rs/handle/123456789/5268
DOI: 10.1002/ar.20838
Appears in Collections:Journal Article

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