Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/5267
Title: Physiological synaptic activity and recognition memory require astroglial glutamine
Authors: Cheung, Giselle
Bataveljić, Danijela 
Visser, Josien
Kumar, Naresh
Moulard, Julien
Dallérac, Glenn
Mozheiko, Daria
Rollenhagen, Astrid
Ezan, Pascal
Mongin, Cédric
Chever, Oana
Bemelmans, Alexis-Pierre
Lübke, Joachim
Leray, Isabelle
Rouach, Nathalie
Keywords: Astrocyte;Cellular neuroscience;Neuronal physiology;Neurotransmitters.
Issue Date: 8-Feb-2022
Rank: M21a
Journal: Nature Communications
Volume: 13
Issue: 1
Start page: 753
Abstract: 
Presynaptic glutamate replenishment is fundamental to brain function. In high activity regimes, such as epileptic episodes, this process is thought to rely on the glutamate-glutamine cycle between neurons and astrocytes. However the presence of an astroglial glutamine supply, as well as its functional relevance in vivo in the healthy brain remain controversial, partly due to a lack of tools that can directly examine glutamine transfer. Here, we generated a fluorescent probe that tracks glutamine in live cells, which provides direct visual evidence of an activity-dependent glutamine supply from astroglial networks to presynaptic structures under physiological conditions. This mobilization is mediated by connexin43, an astroglial protein with both gap-junction and hemichannel functions, and is essential for synaptic transmission and object recognition memory. Our findings uncover an indispensable recruitment of astroglial glutamine in physiological synaptic activity and memory via an unconventional pathway, thus providing an astrocyte basis for cognitive processes.
URI: https://biore.bio.bg.ac.rs/handle/123456789/5267
ISSN: 2041-1723
DOI: 10.1038/s41467-022-28331-7
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