Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/5104
Title: LC-MS Based Analysis and Biological Properties of Pseudocedrela kotschyi (Schweinf.) Harms Extracts: A Valuable Source of Antioxidant, Antifungal, and Antibacterial Compounds
Authors: Sinan, Kouadio Ibrahime
Dall'Acqua, Stefano
Ferrarese, Irene
Mollica, Adriano
Stefanucci, Azzurra
Glamočlija, Jasmina
Soković, Marina
Nenadić, Marija 
Aktumsek, Abdurrahman
Zengin, Gokhan
Keywords: LC-MSn;Pseudocedrela kotschyi;Antimicrobial activity;Antioxidants;Enzyme inhibition;Multi-block discriminant analysis
Issue Date: 2-Oct-2021
Rank: M21a
Publisher: National Library of Medicine
Citation: Cited by Phytochemical Characterization, Anti-Oxidant, Anti-Enzymatic and Cytotoxic Effects of Artemisia verlotiorum Lamotte Extracts: A New Source of Bioactive Agents. Suroowan S, Llorent-Martínez EJ, Zengin G, Dall'Acqua S, Sut S, Buskaran K, Fakurazi S, Mahomoodally MF. Molecules. 2022 Sep 10;27(18):5886. doi: 10.3390/molecules27185886. PMID: 36144622
Journal: Antioxidants
Volume: 10
Issue: 10
Start page: 1570
Abstract: 
The impact of two extraction solvents on the phenolic composition, antioxidant, and enzymes inhibitory and antimicrobial activities of two parts (leaves and stem bark) of P. kotschyi was studied. Two different LC-DAD-MSn approaches were used to identify and quantify the bioactive compounds in the different extracts. A total of thirty-two compounds were quantified, being the procyanidin the most abundant in stem bark while catechin and flavonoids are most abundant in leaves. Overall, the stem bark extraction using methanol showed higher amounts of total phenolic (131.83 ± 1.81 mg GAE/g) and flavanol (14.14 ± 0.11 mg CE/g) while the leaves extraction using water exhibited stronger levels of total flavonoid (44.95 ± 0.38 mg RE/g) and phenolic acid (63.58 ± 2.00 mg CAE/g). As regards the antioxidant assays, methanol stem bark extracts were characterized by the highest antioxidant activities (DPPH: 1.94 ± 0.01 mmol TE/g, ABTS: 3.31 ± 0.01 mmol TE/g, FRAP: 2.86 ± 0.02 mmol TE/g, CUPRAC: 5.09 ± 0.08 mmol TE/g, phosphomolybdenum: 5.16 ± 0.23 mmol TE/g and metal chelating: 17.12 ± 0.46 mg EDTAE/g). In addition, the methanolic extracts of stem bark had highest impact on acetylcholinesterase (2.54 mg GALAE/g), butyrylcholinesterase (5.48 mg GALAE/g). In contrast, the methanolic extracts of leaves was potent against tyrosinase (77.39 ± 0.21 mg KAE/g) and α-glucosidase (0.97 ± 0.01 mmol ACAE/g), while a higher anti-α-amylase (0.97 ± 0.01 mmol ACAE/g) was observed for water extracts of the same part. All of the tested extracts showed inhibitory effects on elastase, except methanolic leaves extracts. Additionally, the extracts exhibited appreciable antifungal toward A. ochraceus, A. fumigatus, P. ochrochloron, T. viride, and P. funiculosum and promising antibacterial activity against M. flavus, S. aureus, L. monocytogenes, E. coli, P. aeruginosa, E. cloacae, and S. typhimurium. Taken together, the outcomes demonstrated P. kotschyi as a novel source of bioactive molecules of interest with an evident therapeutic value.
URI: https://biore.bio.bg.ac.rs/handle/123456789/5104
ISSN: 2076-3921
DOI: 10.3390/antiox10101570
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