Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/5076
Title: Reactive and senescent astroglial phenotypes as hallmarks of brain pathologies
Authors: Lazić, Andrijana
Balint Vanda
Stanisavljević Ninković Danijela
Perić, Mina 
Stevanović, Milena 
Keywords: Astrocytes;Senescence;Reactive astrogliosis;Neurodegenerative diseases;SASP;Astrocyte-targeted therapy;In vitro models
Issue Date: 30-Apr-2022
Rank: M21,
Publisher: MDPI
Citation: Lazic, Andrijana, Vanda Balint, Danijela Stanisavljevic Ninkovic, Mina Peric, and Milena Stevanovic. 2022. "Reactive and Senescent Astroglial Phenotypes as Hallmarks of Brain Pathologies" International Journal of Molecular Sciences 23, no. 9: 4995. https://doi.org/10.3390/ijms23094995
Journal: International Journal of Molecular Sciences
Abstract: 
Astrocytes, as the most abundant glial cells in the central nervous system, are tightly integrated into neural networks and participate in numerous aspects of brain physiology and pathology. They are the main homeostatic cells in the central nervous system, and the loss of astrocyte physiological functions and/or gain of pro-inflammatory functions, due to their reactivation or cellular senescence, can have profound impacts on the surrounding microenvironment with pathological outcomes. Although the importance of astrocytes is generally recognized, and both senescence and reactive astrogliosis have been extensively reviewed independently, there are only a few comparative overviews of these complex processes. In this review, we summarize the latest data regarding astrocyte reactivation and senescence, and outline similarities and differences between these phenotypes from morphological, functional, and molecular points of view. A special focus has been given to neurodegenerative diseases, where these phenotypic alternations of astrocytes are significantly implicated. We also summarize current perspectives regarding new advances in model systems based on astrocytes as well as data pointing to these glial cells as potential therapeutic targets.
URI: https://biore.bio.bg.ac.rs/handle/123456789/5076
ISSN: 1422-0067
DOI: 10.3390/ijms23094995
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