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Title: | Analysis of association between polymorphisms of MTHFR, MTHFD1 and RFC1 genes and efficacy and toxicity of methotrexate in rheumatoid arthritis patients |
Authors: | Vejnovic, Dubravka Milic, Vera Damnjanovic, Tatjana Maksimovic, Nela Bunjevacki, Vera Lukovic, Ljiljana Novakovic, Ivana Krajinovic, Maja Damjanov, Nemanja Radunovic, Goran Pavković Lučić, Sofija Jekic, Biljana |
Keywords: | Genetic polymorphism;Methotrexate;MTHFD1;MTHFR;RFC1;Rheumatoid arthritis |
Issue Date: | 1-Jan-2016 |
Rank: | M23 |
Journal: | Genetika |
Volume: | 48 |
Issue: | 1 |
Start page: | 395 |
End page: | 408 |
Abstract: | A folate analogue methotrexate (MTX) is the most commonly used disease-modifying drug in the treatment of rheumatoid arthritis. However, the clinical response of RA patients treated with MTX shows interindividual differences and 30% of patients discontinue therapy due to the side effects. In a group of 184 RA patients treated with MTX we have investigated whether polymorphisms in MTHFR (rs1801133,... |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/505 |
ISSN: | 0534-0012 |
DOI: | 10.2298/GENSR1601395V |
Appears in Collections: | Journal Article |
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