Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/505
Title: Analysis of association between polymorphisms of MTHFR, MTHFD1 and RFC1 genes and efficacy and toxicity of methotrexate in rheumatoid arthritis patients
Authors: Vejnovic, Dubravka
Milic, Vera
Damnjanovic, Tatjana
Maksimovic, Nela
Bunjevacki, Vera
Lukovic, Ljiljana
Novakovic, Ivana
Krajinovic, Maja
Damjanov, Nemanja
Radunovic, Goran
Pavković Lučić, Sofija 
Jekic, Biljana
Keywords: Genetic polymorphism;Methotrexate;MTHFD1;MTHFR;RFC1;Rheumatoid arthritis
Issue Date: 1-Jan-2016
Rank: M23
Journal: Genetika
Volume: 48
Issue: 1
Start page: 395
End page: 408
Abstract: 
A folate analogue methotrexate (MTX) is the most commonly used disease-modifying drug in the treatment of rheumatoid arthritis. However, the clinical response of RA patients treated with MTX shows interindividual differences and 30% of patients discontinue therapy due to the side effects. In a group of 184 RA patients treated with MTX we have investigated whether polymorphisms in MTHFR (rs1801133,...
URI: https://biore.bio.bg.ac.rs/handle/123456789/505
ISSN: 0534-0012
DOI: 10.2298/GENSR1601395V
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