Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/504
Title: Chemical defence in a millipede: Evaluation and characterization of antimicrobial activity of the defensive secretion from Pachyiulus hungaricus (Karsch, 1881) (Diplopoda, Julida, Julidae)
Authors: Stanković, Slaviša 
Dimkić, Ivica 
Vujisić, Ljubodrag
Pavković Lučić, Sofija 
Jovanović, Zvezdana 
Stević, Tatjana
Sofrenić, Ivana
Mitić, Bojan 
Tomić, Vladimir 
Issue Date: 1-Dec-2016
Rank: M21
Journal: PLoS ONE
Volume: 11
Issue: 12
Start page: e0167249
Abstract: 
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The chemical defence of the millipede Pachyiulus hungaricus is reported in the present paper, in which a chemical characterization is given and antimicrobial activity is determined. In total, independently of sex, 44 compounds were identified. All compounds belong to two groups: quinones and pentyl and hexyl esters of long-chain fatty acids. The relative abundances of quinones and non-quinones were 94.7% vs. 5.3% (males) and 87.3% vs. 12.7% (females), respectively. The two dominant quinones in both sexes were 2-methyl-1,4,-benzoquinone and 2-methoxy-3-methyl-1,4-benzoquinone. Antibacterial and antifungal activity of the defensive secretion was evaluated in vitro against seven bacterial strains and eight fungal species. With the aid of a dilution technique, the antimicrobial potential of the secretion and high sensitivity of all tested strains were confirmed. The lowest minimum concentrations of these compounds (0.20-0.25 mg/mL) were sufficient for inhibition of Aeromonas hydrophila, Listeria monocytogenes and Methicillin resistant Staphylococcus aureus (MRSA). The growth of eight tested fungal species was inhibited by slightly lower concentrations of the secretion, with Fusarium equiseti as the most sensitive fungus and Aspergillus flavus as the most resistant. Values of MIC and MFC in the employed microdilution assay ranged from 0.10 to above 0.35 mg/mL. The given extract contains antimicrobial components potentially useful as therapeutic agents in the pharmaceutical and agricultural industries.
URI: https://biore.bio.bg.ac.rs/handle/123456789/504
DOI: 10.1371/journal.pone.0167249
Appears in Collections:Journal Article

Show full item record

SCOPUSTM   
Citations

16
checked on Nov 1, 2024

Page view(s)

5
checked on Nov 4, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.