Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/500
Title: Tenascin-C and its functions in neuronal plasticity
Authors: Sekeljic, Vera 
Anđus, Pavle 
Keywords: Central nervous system;Extracellular matrix;Fibronectin-like repeats 6-8;Synaptic plasticity;Tenascin-C
Issue Date: 1-Jan-2012
Journal: International Journal of Biochemistry and Cell Biology
Abstract: 
The extracellular matrix glycoprotein tenascin-C (TN-C), a molecule highly conserved in vertebrates, is widely expressed in neural and non-neural tissue during development, repair processes in the adult organism, and tumorigenesis. In the developing central nervous system (CNS), in different brain regions TN-C is expressed in specific spatial and temporal patterns. In the adult CNS, its expression remains in areas of active neurogenesis and areas that exhibit neuronal plasticity. Understanding of the contribution of this extracellular matrix constituent to the major developmental processes such as cell proliferation and migration, axonal guidance, as well as synaptic plasticity, is derived from studies on TN-C deficient mice. Studies on these mice demonstrated that TN-C plays an important role in neuronal plasticity in the cerebral cortex, hippocampus and cerebellum, possibly by modulating the activity of L-type voltage-dependent Ca2+ channels. © 2012 Elsevier Ltd.
URI: https://biore.bio.bg.ac.rs/handle/123456789/500
ISSN: 1357-2725
DOI: 10.1016/j.biocel.2012.02.014
Appears in Collections:Journal Article

Files in This Item:
File Description SizeFormat Existing users please
40 TenascinC-and-its-functions-in-neuronal-plasticity.pdf970.72 kBAdobe PDF
    Request a copy
Show full item record

SCOPUSTM   
Citations

19
checked on Nov 2, 2024

Page view(s)

1
checked on Nov 4, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.