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Title: | Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis | Authors: | Đukić-Ćosić, Danijela Baralić, Katarina Filipović, Teodora Božić, Dragica Živančević, Katarina S. Antonijević Miljaković Evica Buha Đorđević, Aleksandra Bulat, Zorica Antonijević, Biljana Ćurčić, Marijana |
Keywords: | SARS-CoV-2;Carbon monoxide;Citokini;Cytokines;Disease complications;dušikov dioksid;In silico;Komplikacije bolesti;Lebdeće čestice;Nitrogen dioxide;Onečišćivači zraka;Ozon particulate matter;Poremećaj funkcije gena;Sulphur dioxide;Sumporov dioksid;Ugljikov monoksid | Issue Date: | 7-Jul-2022 | Rank: | M22 | Citation: | Đukić-Ćosić D, Baralić K, Filipović T, Božić D, Živančević K, Miljaković EA, Đorđević AB, Bulat Z, Antonijević B, Ćurčić M. Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis. Arh Hig Rada Toksikol. 2022 Jul 7;73(2):119-125. doi: 10.2478/aiht-2022-73-3631. PMID: 35792766; PMCID: PMC9287838. | Journal: | Arhiv za higijenu rada i toksikologiju | Abstract: | Considering that some researchers point to a possible influence of air pollution on COVID-19 transmission, severity, and death rate, the aim of our in silico study was to determine the relationship between the key air pollutants [sulphur dioxide (SO), carbon monoxide (CO), 2particulate matter (PMx), nitrogen dioxide (NO2), and ozone (O3)] and COVID-19 complications using the publicly available toxicogenomic analytical and prediction tools: (i) Comparative Toxicogenomic Database (CTD) to identify genes common to air pollutants and COVID-19 complications; (ii) GeneMANIA to construct a network of these common and related genes; (iii) ToppGene Suite to extract the most important biological processes and molecular pathways; and (iv) DisGeNET to search for the top gene-disease pairs. SO2, CO, PMx, NO2, and O3 interacted with 6, 6, 18, 9, and 12 COVID-19-related genes, respectively. Four of these are common for all pollutants (IL10, IL6, IL1B, and TNF) and participate in most (77.64 %) physical interactions. Further analysis pointed to cytokine binding and cytokine-mediated signalling pathway as the most important molecular function and biological process, respectively. Other molecular functions and biological processes are mostly related to cytokine activity and inflammation, which might be connected to the cytokine storm and resulting COVID-19 complications. The final step singled out the link between the CEBPA gene and acute myelocytic leukaemia and between TNFRSF1A and TNF receptor-associated periodic fever syndrome. This indicates possible complications in COVID-19 patients suffering from these diseases, especially those living in urban areas with poor air quality. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/4999 | ISSN: | 0004-1254 1848-6312 |
DOI: | 10.2478/aiht-2022-73-3631 |
Appears in Collections: | Journal Article |
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