Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4989
Title: Novel RclSAR three-component system regulates expression of the intI1 gene in the stationary growth phase
Authors: Novović, Katarina
Malešević, Milka
Gardijan, Lazar
Kojić, Milan
Jovčić, Branko 
Keywords: Three-component system;Sensor histidine kinase;Integrase;Integron;Pseudomonas;Transcriptional regulation
Issue Date: Jan-2022
Rank: M22
Publisher: ELSEVIER
Citation: RclS Sensor Kinase Modulates Virulence of Pseudomonas capeferrum 2022, International Journal of Molecular Sciences
Journal: Research in Microbiology
Abstract: 
The rapid and appropriate response of Pseudomonas spp. to environmental fluctuations has been enabled by numerous signal transduction regulatory systems. Regulatory systems in Pseudomonas aeruginosa are organized in a complex network which provides quick and fine-tuned cellular response through regulation of virulence and antibiotic resistance determinants production. Mobile integrons represent genetic elements included in the rapid dissemination of multiple antibiotic resistance determinants. The key factor of integron dynamics is enzyme integrase. So far, global regulators LexA, RpoS and PsrA have been recognized as regulators of the intI1 transcription. In this study, we discovered novel activator of the intI1 transcription, sensor kinase RclS, in Pseudomonas putida WCS358. This regulation is limited to stationary growth phase and appears to be indirect, at least through regulation of the rpoS expression. Sensor kinase RclS is a part of novel three-component system Rcl (Roc-like) together with two response regulators, RclR and RclA. RclS acted as a negative regulator of the rclA transcription, while the role in the rclR transcription regulation could not be defined. The RclSAR regulatory system seems to be a part of complex intI1 regulatory network which includes major stress response (SOS and RpoS) regulons.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4989
ISSN: 0923-2508
DOI: 10.1016/j.resmic.2021.103885
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