Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/4705
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Radovanović, Jelena | en_US |
dc.contributor.author | Antonijević, Biljana | en_US |
dc.contributor.author | Ćurčić, Marijana | en_US |
dc.contributor.author | Baralić, Katarina | en_US |
dc.contributor.author | Kolarević, Stoimir | en_US |
dc.contributor.author | Bulat, Zorica | en_US |
dc.contributor.author | Đukić-Ćosić, Danijela | en_US |
dc.contributor.author | Buha Djordjević, Aleksandra | en_US |
dc.contributor.author | Vuković-Gačić, Branka | en_US |
dc.contributor.author | Javorac, Dragana | en_US |
dc.contributor.author | Antonijević Miljaković, Evica | en_US |
dc.contributor.author | Carević, Momir | en_US |
dc.contributor.author | Mandinić, Zoran | en_US |
dc.date.accessioned | 2022-10-31T11:58:35Z | - |
dc.date.available | 2022-10-31T11:58:35Z | - |
dc.date.issued | 2022-12-01 | - |
dc.identifier.uri | https://biore.bio.bg.ac.rs/handle/123456789/4705 | - |
dc.description.abstract | Excessive fluoride (F-) levels in the environment could induce different pathological changes, including comorbidities in reproductive functions. Hence, the aim of the present in vivo study was to explore F- subacute toxicity mechanisms via Benchmark dose (BMD) methodology on rat's testicles. The experiment was conducted on thirty male Wistar rats for 28 days, divided into six groups (n = 5): 1) Control (tap water); 2) 10 mg/L F-; 3) 25 mg/L F-; 4) 50 mg/L F-; 5) 100 mg/L F-; 6) 150 mg/L F-. Testicles were dissected out and processed for the determination of F- tissue concentrations, redox status parameters, essential elements level, and DNA damage. PROASTweb 70.1 software was used for determination of external and internal dose-response relationship. The results confirmed a significant increase in superoxide anion (O2.-), total oxidative status (TOS), copper (Cu), zinc (Zn), iron (Fe), DNA damage levels, and decrease in superoxide dismutase activity (SOD1) and total thiol (SH) groups. The dose-dependent changes were confirmed for SOD1 activity and DNA damage. The most sensitive parameters were SOD1 activity and DNA damage with the lowest BMDLs 0.1 μg F-/kg b. w. Since human and animal populations are daily and frequently unconsciously exposed to F-, this dose-response study is valuable for further research regarding the F- health risk assessment. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Ltd | en_US |
dc.relation.ispartof | Environmental Pollution | en_US |
dc.subject | Benchmark methodology | en_US |
dc.subject | Bioelements | en_US |
dc.subject | Comet assay | en_US |
dc.subject | Fluoride | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Testicles | en_US |
dc.title | Fluoride subacute testicular toxicity in Wistar rats: Benchmark dose analysis for the redox parameters, essential elements and DNA damage | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.envpol.2022.120321. | - |
dc.description.rank | M21 | en_US |
dc.description.impact | 9.988 | en_US |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Chair of Microbiology | - |
crisitem.author.dept | Chair of Microbiology | - |
crisitem.author.orcid | 0000-0002-6938-8803 | - |
crisitem.author.orcid | 0000-0001-8767-1912 | - |
Appears in Collections: | Journal Article |
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