Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4705
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dc.contributor.authorRadovanović, Jelenaen_US
dc.contributor.authorAntonijević, Biljanaen_US
dc.contributor.authorĆurčić, Marijanaen_US
dc.contributor.authorBaralić, Katarinaen_US
dc.contributor.authorKolarević, Stoimiren_US
dc.contributor.authorBulat, Zoricaen_US
dc.contributor.authorĐukić-Ćosić, Danijelaen_US
dc.contributor.authorBuha Djordjević, Aleksandraen_US
dc.contributor.authorVuković-Gačić, Brankaen_US
dc.contributor.authorJavorac, Draganaen_US
dc.contributor.authorAntonijević Miljaković, Evicaen_US
dc.contributor.authorCarević, Momiren_US
dc.contributor.authorMandinić, Zoranen_US
dc.date.accessioned2022-10-31T11:58:35Z-
dc.date.available2022-10-31T11:58:35Z-
dc.date.issued2022-12-01-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/4705-
dc.description.abstractExcessive fluoride (F-) levels in the environment could induce different pathological changes, including comorbidities in reproductive functions. Hence, the aim of the present in vivo study was to explore F- subacute toxicity mechanisms via Benchmark dose (BMD) methodology on rat's testicles. The experiment was conducted on thirty male Wistar rats for 28 days, divided into six groups (n = 5): 1) Control (tap water); 2) 10 mg/L F-; 3) 25 mg/L F-; 4) 50 mg/L F-; 5) 100 mg/L F-; 6) 150 mg/L F-. Testicles were dissected out and processed for the determination of F- tissue concentrations, redox status parameters, essential elements level, and DNA damage. PROASTweb 70.1 software was used for determination of external and internal dose-response relationship. The results confirmed a significant increase in superoxide anion (O2.-), total oxidative status (TOS), copper (Cu), zinc (Zn), iron (Fe), DNA damage levels, and decrease in superoxide dismutase activity (SOD1) and total thiol (SH) groups. The dose-dependent changes were confirmed for SOD1 activity and DNA damage. The most sensitive parameters were SOD1 activity and DNA damage with the lowest BMDLs 0.1 μg F-/kg b. w. Since human and animal populations are daily and frequently unconsciously exposed to F-, this dose-response study is valuable for further research regarding the F- health risk assessment.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofEnvironmental Pollutionen_US
dc.subjectBenchmark methodologyen_US
dc.subjectBioelementsen_US
dc.subjectComet assayen_US
dc.subjectFluorideen_US
dc.subjectOxidative stressen_US
dc.subjectTesticlesen_US
dc.titleFluoride subacute testicular toxicity in Wistar rats: Benchmark dose analysis for the redox parameters, essential elements and DNA damageen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.envpol.2022.120321.-
dc.description.rankM21en_US
dc.description.impact9.988en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Microbiology-
crisitem.author.deptChair of Microbiology-
crisitem.author.orcid0000-0002-6938-8803-
crisitem.author.orcid0000-0001-8767-1912-
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