Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4660
Title: Antimicrobial Susceptibility Testing: A Comprehensive Review of Currently Used Methods
Authors: Gajić, Ina
Kabić, Jovana
Kekić, Dušan
Jovičević, Miloš
Milenković, Marina
Mitić-Ćulafić, Dragana 
Trudić, Anika
Ranin, Lazar
Opavski, Nataša
Keywords: Antimicrobial resistance;Antimicrobial susceptibility testing;Methods
Issue Date: 23-Mar-2022
Rank: M21
Publisher: National Library of Medicine
Journal: Antibiotics
Abstract: 
Antimicrobial resistance (AMR) has emerged as a major threat to public health globally. Accurate and rapid detection of resistance to antimicrobial drugs, and subsequent appropriate antimicrobial treatment, combined with antimicrobial stewardship, are essential for controlling the emergence and spread of AMR. This article reviews common antimicrobial susceptibility testing (AST) methods and relevant issues concerning the advantages and disadvantages of each method. Although accurate, classic technologies used in clinical microbiology to profile antimicrobial susceptibility are time-consuming and relatively expensive. As a result, physicians often prescribe empirical antimicrobial therapies and broad-spectrum antibiotics. Although recently developed AST systems have shown advantages over traditional methods in terms of testing speed and the potential for providing a deeper insight into resistance mechanisms, extensive validation is required to translate these methodologies to clinical practice. With a continuous increase in antimicrobial resistance, additional efforts are needed to develop innovative, rapid, accurate, and portable diagnostic tools for AST. The wide implementation of novel devices would enable the identification of the optimal treatment approaches and the surveillance of antibiotic resistance in health, agriculture, and the environment, allowing monitoring and better tackling the emergence of AMR.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4660
DOI: 10.3390/antibiotics11040427
Appears in Collections:Journal Article

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