Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4547
Title: Assessment of the Biological Effects of Pellia endiviifolia and its Constituents in Vitro
Authors: Ivković, Ivana
Bukvički, Danka 
Novaković, Miroslav
Majstorović, Ivana
Leskovac, Andreja
Petrović, Sandra
Veljić, Milan 
Keywords: Perrottetin E;10′ -hydroxyperrottetin E;10,10′ -dihydroxyperrottetin E;Micronuclei;Catalase activity;Malondialdehyde;Apoptosis
Issue Date: 20-Nov-2021
Rank: M23
Publisher: SAGE
Citation: . Ivković I, Bukvički D, Novaković M, et al. Assessment of the Biological Effects of Pellia endiviifolia and its Constituents in Vitro. Natural Product Communications. November 2021. doi:10.1177/1934578X211056422
Journal: Natural Product Communications
Abstract: 
Liverworts are characterized by a high content of bioactive compounds reported to show antimicrobial, anticancer, and antioxidant properties. In this study, the biological effects of the methanol extract of the liverwort Pellia endiviifolia and its constituents, bis-bibenzyls perrottetin E, 10′ -hydroxyperrottetin E, and 10,10′-dihydroxyperrottetin E, were investigated using human peripheral bloodells as a model system. The assessment of the investigated compounds comprised testing their genotoxicity, apoptotic potential,
and redox modulating activities. The genotoxicity testing indicated that medium (25 µM) and high concentrations (100 µM) of the investigated compounds displayed genotoxic and antiproliferative effects in human lymphocytes as revealed by significant, concentration-dependent enhancement of the micronuclei incidence and decrease in the cytokinesis-block proliferation index compared to the control (P < .001). Analysis of leukocyte apoptosis showed a substantial potential of all investigated compounds to induce
apoptosis, which was not concentration-dependent. The P endiviifolia extract and perrottetin E demonstrated considerable pro-apoptotic potential, even at the lowest concentration (1 µM) applied. Evaluation of the redox modulating effects, which comprised measuring erythrocyte catalase activity and the lymphocyte malondialdehyde level, showed that the investigated compounds did not induce oxidative stress in human peripheral blood cells (P > .05). The observed genotoxic, antiproliferative, and proapoptotic effects of the investigated compounds make them suitable for further comprehensive studies related to their possible applications as anticancer agents.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4547
ISSN: 1934-578X
1555-9475
DOI: 10.1016/S0021-9258(19)52451-6
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