Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4495
Title: Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives
Authors: Đukanović, Nina
Obradović, Slobodan
Zdravković, Marija
Đurašević, Siniša 
Stojković, Maja
Tosti, Tomislav
Jasnić, Nebojša 
Đorđević, Jelena 
Todorović, Zoran
Keywords: P2Y12 inhibitors;discontinuation;HDL
Issue Date: 20-Mar-2021
Rank: M21
Publisher: MDPI
Journal: International Journal of Molecular Sciences
Abstract: 
Lipids play an essential role in platelet functions. It is known that polyunsaturated fatty
acids play a role in increasing platelet reactivity and that the prothrombotic phenotype plays a crucial
role in the occurrence of major adverse cardiovascular events. The ongoing increase in cardiovascular
diseases’ incidence emphasizes the importance of research linking lipids and platelet function. In
particular, the rebound phenomenon that accompanies discontinuation of clopidogrel in patients
receiving dual antiplatelet therapy has been associated with changes in the lipid profile. Our many
years of research underline the importance of reduced HDL values for the risk of such a rebound
effect and the occurrence of thromboembolic events. Lipids are otherwise a heterogeneous group of
molecules, and their signaling molecules are not deposited but formed “on-demand” in the cell. On
the other hand, exosomes transmit lipid signals between cells, and the profile of such changes can be
monitored by lipidomics. Changes in the lipid profile are organ-specific and may indicate new drug
action targets.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4495
ISSN: 1422-0067
DOI: 10.3390/ijms22063180
Appears in Collections:Journal Article

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