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Title: | The effects of meldonium on the acute ischemia/reperfusion liver injury in rats | Authors: | Đurašević, Siniša Stojković, Maja Sopta, Jelena Pavlović, Slađan Borković-Mitić, Slavica Ivanović, Anđelija Jasnić, Nebojša Tosti, Tomislav Đurović, Saša Đorđević, Jelena Todorović, Zoran |
Keywords: | meldonium;ischemia;reperfusion;liver injury | Issue Date: | 1-Jan-2021 | Rank: | M21 | Publisher: | Nature Research | Journal: | Scientific Reports | Abstract: | Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygenconsuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by attenuation of serum alanine- and aspartate aminotransferase activity, serum and liver high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and the phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells. Through the increased hepatic activation of the nuclear factor erythroid 2-related factor 2, meldonium improves the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum and liver ascorbic/dehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione and free thiol groups content, and hepatic copper-zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver injury, with a clinical significance in surgical procedures. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/4494 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-020-80011-y |
Appears in Collections: | Journal Article |
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