Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4493
Title: Lipidomics Provides New Insight into Pathogenesis and Therapeutic Targets of the Ischemia—Reperfusion Injury
Authors: Todorović, Zoran
Đurašević, Siniša 
Stojković, Maja
Grigorov, Ilijana
Pavlović, Slađan
Jasnić, Nebojša 
Tosti, Tomislav
Macut, Jelica Bjekić
Thiemermann, Christoph
Đorđević, Jelena 
Keywords: ischemia/reperfusion;lipidomics;kidney;liver
Issue Date: 1-Mar-2021
Publisher: MDPI
Journal: International Journal of Molecular Sciences
Abstract: 
Lipids play an essential role in both tissue protection and damage. Tissue ischemia creates
anaerobic conditions in which enzyme inactivation occurs, and reperfusion can initiate oxidative
stress that leads to harmful changes in membrane lipids, the formation of aldehydes, and chain
damage until cell death. The critical event in such a series of harmful events in the cell is the
unwanted accumulation of fatty acids that leads to lipotoxicity. Lipid analysis provides additional
insight into the pathogenesis of ischemia/reperfusion (I/R) disorders and reveals new targets for
drug action. The profile of changes in the composition of fatty acids in the cell, as well as the time
course of these changes, indicate both the mechanism of damage and new therapeutic possibilities.
A therapeutic approach to reperfusion lipotoxicity involves attenuation of fatty acids overload, i.e.,
their transport to adipose tissue and/or inhibition of the adverse effects of fatty acids on cell damage
and death. The latter option involves using PPAR agonists and drugs that modulate the transport of
fatty acids via carnitine into the interior of the mitochondria or the redirection of long-chain fatty
acids to peroxisomes.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4493
ISSN: 1422-0067
DOI: 10.3390/ijms22062798
Appears in Collections:Journal Article

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