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Title: | Sex-specific effects of sympatric mitonuclear variation on fitness in Drosophila subobscura Genome evolution and evolutionary systems biology Genome evolution and evolutionary systems biology | Authors: | Jelić, Mihailo Arnqvist, Göran Kurbalija Novičić, Zorana Kenig, Bojan Tanasković, Marija Ancrossed D Signelković, Marko Stamenković Radak, Marina |
Keywords: | Fruit fly;Life history traits;Mitochondria;Mitonuclear epistasis;Selection;Sexual dimorphism | Issue Date: | 10-Jul-2015 | Journal: | BMC Evolutionary Biology | Abstract: | © 2015 Jelić et al. Background: A number of recent studies have shown that the pattern of mitochondrial DNA variation and evolution is at odds with a neutral equilibrium model. Theory has suggested that selection on mitonuclear genotypes can act to maintain stable mitonuclear polymorphism within populations. However, this effect largely relies upon selection being either sex-specific or frequency dependent. Here, we use mitonuclear introgression lines to assess differences in a series of key life-history traits (egg-to-adult developmental time, viability, offspring sex-ratio, adult longevity and resistance to desiccation) in Drosophila subobscura fruit flies carrying one of three different sympatric mtDNA haplotypes. Results: We found functional differences between these sympatric mtDNA haplotypes, but these effects were contingent upon the nuclear genome with which they were co-expressed. Further, we demonstrate a significant mitonuclear genetic effect on adult sex ratio, as well as a sex∈×∈mtDNA∈×∈nuDNA interaction for adult longevity. Conclusions: The observed effects suggest that sex specific mitonuclear selection contributes to the maintenance of mtDNA polymorphism and to mitonuclear linkage disequilibrium in this model system. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/432 | DOI: | 10.1186/s12862-015-0421-2 |
Appears in Collections: | Journal Article |
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