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https://biore.bio.bg.ac.rs/handle/123456789/4318
Title: | Lactate metabolism in breast cancer microenvironment: contribution focused on associated adipose tissue and obesity |
Authors: | Kalezić, A Udicki, M Srdić Galić, B Aleksić, Marija Korać, Aleksandra Janković, A. Korać, Bato |
Keywords: | Cancer-associated adipose tissue;Lactate;Lactate dehydrogenase;Obesity;Premenopausal breast cancer |
Issue Date: | 18-Dec-2020 |
Rank: | M21 |
Publisher: | National Library of Medicine |
Journal: | International Journal of Molecular Sciences |
Volume: | 21 |
Issue: | 24 |
Start page: | 9676 |
Abstract: | Metabolic reprogramming that favors high glycolytic flux with lactate production in normoxia is among cancer hallmarks. Lactate is an essential oncometabolite regulating cellular redox homeostasis, energy substrate partitioning, and intracellular signaling. Moreover, malignant phenotype's chief characteristics are dependent on the interaction between cancer cells and their microenvironment. In bre... |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/4318 |
DOI: | 10.3390/ijms21249676 |
Appears in Collections: | Journal Article |
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