Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4268
Title: Genotoxicity of fluoride subacute exposure in rats and selenium intervention
Authors: Radovanović, Jelena
Antonijević, Biljana
Kolarević, Stoimir 
Milutinović-Smiljanić, Sanja
Mandić, Jelena
Vuković-Gačić, Branka 
Bulat, Zorica
Ćurčić, Marijana
Kračun-Kolarević, Margareta
Sunjog, Karolina
Kostić-Vuković, Jovana
Marić, Jovana Jovanović
Antonijević-Miljaković, Evica
Đukić-Ćosić, Danijela
Djordjevic, Aleksandra Buha
Javorac, Dragana
Baralić, Katarina
Mandinić, Zoran
Keywords: Comet assay;DNA damage;NaF;Subacute toxicity;Wistar rats
Issue Date: 2021
Rank: M21
Publisher: Elsevier Ltd
Citation: Jelena Radovanović, Biljana Antonijević, Stoimir Kolarević, Sanja Milutinović-Smiljanić, Jelena Mandić, Branka Vuković-Gačić, Zorica Bulat, Marijana Ćurčić, Margareta Kračun-Kolarević, Karolina Sunjog, Jovana Kostić-Vuković, Jovana Jovanović Marić, Evica Antonijević-Miljaković, Danijela Đukić-Ćosić, Aleksandra Buha Djordjevic, Dragana Javorac, Katarina Baralić, Zoran Mandinić, Genotoxicity of fluoride subacute exposure in rats and selenium intervention, Chemosphere, Volume 266, 2021,128978,
Journal: Chemosphere
Abstract: 
The aims of this study were to: (i) examine the toxic effects of sodium fluoride (NaF) in blood, liver, spleen, and brain cells of Wistar rats after the subacute exposure; (ii) explore the potential protective properties of selenium (Se) against fluoride toxicity after the simultaneous administration. Twenty male Wistar rats, eight weeks old, weighing approximately 140–190 g, were divided into four experimental groups (n = 5) as follows: I control-tap water; II NaF 150 ppm; III NaF 150 ppm and Se 1.5 mg/L; IV Se 1.5 mg/L, and had available water with solutions ad libitum for 28 days. DNA damage detected by comet assay was confirmed in the liver, spleen, and brain cells, but not in blood. Selenium supplementation together with NaF decreased DNA damage in liver and spleen cells. According to the histological findings, no changes were observed in spleen and brain tissues after NaF administration. Unlike the observed Se protective effect on the DNA level, no significant reduction of liver tissue injury was observed after the NaF and Se treatment, resulting in mild inflammation. Data of this study suggest that DNA damage after NaF subacute exposure at moderately high concentration was reduced in liver and spleen cells due to Se supplementation, but a similar change was not seen in the brain.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4268
ISSN: 0045-6535
DOI: 10.1016/j.chemosphere.2020.128978
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