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Title: | Genotoxicity of fluoride subacute exposure in rats and selenium intervention | Authors: | Radovanović, Jelena Antonijević, Biljana Kolarević, Stoimir Milutinović-Smiljanić, Sanja Mandić, Jelena Vuković-Gačić, Branka Bulat, Zorica Ćurčić, Marijana Kračun-Kolarević, Margareta Sunjog, Karolina Kostić-Vuković, Jovana Marić, Jovana Jovanović Antonijević-Miljaković, Evica Đukić-Ćosić, Danijela Djordjevic, Aleksandra Buha Javorac, Dragana Baralić, Katarina Mandinić, Zoran |
Keywords: | Comet assay;DNA damage;NaF;Subacute toxicity;Wistar rats | Issue Date: | 2021 | Rank: | M21 | Publisher: | Elsevier Ltd | Citation: | Jelena Radovanović, Biljana Antonijević, Stoimir Kolarević, Sanja Milutinović-Smiljanić, Jelena Mandić, Branka Vuković-Gačić, Zorica Bulat, Marijana Ćurčić, Margareta Kračun-Kolarević, Karolina Sunjog, Jovana Kostić-Vuković, Jovana Jovanović Marić, Evica Antonijević-Miljaković, Danijela Đukić-Ćosić, Aleksandra Buha Djordjevic, Dragana Javorac, Katarina Baralić, Zoran Mandinić, Genotoxicity of fluoride subacute exposure in rats and selenium intervention, Chemosphere, Volume 266, 2021,128978, | Journal: | Chemosphere | Abstract: | The aims of this study were to: (i) examine the toxic effects of sodium fluoride (NaF) in blood, liver, spleen, and brain cells of Wistar rats after the subacute exposure; (ii) explore the potential protective properties of selenium (Se) against fluoride toxicity after the simultaneous administration. Twenty male Wistar rats, eight weeks old, weighing approximately 140–190 g, were divided into four experimental groups (n = 5) as follows: I control-tap water; II NaF 150 ppm; III NaF 150 ppm and Se 1.5 mg/L; IV Se 1.5 mg/L, and had available water with solutions ad libitum for 28 days. DNA damage detected by comet assay was confirmed in the liver, spleen, and brain cells, but not in blood. Selenium supplementation together with NaF decreased DNA damage in liver and spleen cells. According to the histological findings, no changes were observed in spleen and brain tissues after NaF administration. Unlike the observed Se protective effect on the DNA level, no significant reduction of liver tissue injury was observed after the NaF and Se treatment, resulting in mild inflammation. Data of this study suggest that DNA damage after NaF subacute exposure at moderately high concentration was reduced in liver and spleen cells due to Se supplementation, but a similar change was not seen in the brain. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/4268 | ISSN: | 0045-6535 | DOI: | 10.1016/j.chemosphere.2020.128978 |
Appears in Collections: | Journal Article |
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