Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4251
Title: Variation in genes coding for cyclin D1 and p21 and oral squamous cell carcinoma risk and prognosis
Authors: Jovic, Sasa
Zeljić, Katarina 
Ivkovic, Nemanja
Stefik, Debora
Kozomara, Ruzica
Stosic, Srboljub
Supic, Gordana
Keywords: p21;cyclin D1;gene polymorphism;oral squamous cell carcinoma
Issue Date: 2021
Rank: M23
Citation: TI - Cyclin D1 and p21 gene variants and oral squamous cell carcinoma risk and prognosis Jović Saša,Zeljić Katarina,Ivković Nemanja,Štefik Debora,Kozomara Ružica, Stošić Srboljub,Šupić Gordana; Archives of Biological Sciences,2021 (On Line First), pg. 37
Journal: Archives of Biological Sciences
Abstract: 
Cyclin-dependent kinase inhibitor p21 (encoded by the CDKN1A gene) and cyclin D1 (encoded by the CCND1 gene) are important regulators of cell cycle progression and could have important effects in the complex process of neoplastic transformation. The current study aimed to investigate variants in CDKN1A (rs1801270, rs1059234) and CCND1 (rs9344) genes as potential risk and prognostic factors in oral squamous cell carcinoma (OSCC) patients. The study included 104 OSCC patients and 107 healthy individuals without a history of cancer. Genotypes were assessed by real-time PCR and TaqMan SNP genotyping. Significant differences in genotype distribution between OSCC cases and the control group were observed for the CCND1 rs9344 variant (p=0.017). According to the odds ratio (OR), adjusted for age and sex, the rs9344 heterozygous GA and homozygous mutated AA genotypes were associated with an increased OSCC susceptibility (OR=2.295, p=0.007; OR=2.029, p=0.037, respectively). Variants rs1801270 and rs105923 in CDKN1A were not associated with OSCC risk. There were no differences in overall survival among OSCC patients stratified by genotypes of the analyzed variants in CDKN1A and CCND1. Variant rs9344 in the CCND1 gene might be considered as a potential molecular risk factor for OSCC susceptibility but not for disease prognosis.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4251
ISSN: 0354-4664
1821-4339
DOI: 10.2298/ABS210813037J
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