Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4209
Title: The microbiome of bat guano: for what is this knowledge important?
Authors: Dimkić, Ivica 
Fira, Djordje
Janakiev, Tamara 
Kabić, Jovana
Stupar, Miloš 
Nenadić, Marija 
Unković, Nikola 
Ljaljević-Grbić, Milica 
Keywords: Bat guano;Microbiota;Zoonoses;Pathogens;Disease outbreaks
Issue Date: 2021
Rank: M21
Journal: Applied Microbiology and Biotechnology
Abstract: 
Bats as flying mammals are potent vectors and natural reservoir hosts for many infectious viruses, bacteria, and fungi, also
detected in their excreta such as guano. Accelerated deforestation, urbanization, and anthropization hastily lead to overpopulation
of the bats in urban areas allowing easy interaction with other animals, expansion, and emergence of new zoonotic disease
outbreaks potentially harmful to humans. Therefore, getting new insights in the microbiome of bat guano from different places
represents an imperative for the future. Furthermore, the use of novel high-throughput sequencing technologies allows better
insight in guano microbiome and potentially indicated that some species could be typical guano-dwelling members. Bats are well
known as a natural reservoir of many zoonotic viruses such as Ebola, Nipah, Marburg, lyssaviruses, rabies, henipaviruses, and
many coronaviruses which caused a high number of outbreaks including ongoing COVID-19 pandemic. Additionally, many
bacterial and fungal pathogens were identified as common guano residents. Thus, the presence of multi-drug-resistant bacteria as
environmental reservoirs of extended spectrum β-lactamases and carbapenemase-producing strains has been confirmed. Bat
guano is the most suitable substrate for fungal reproduction and dissemination, including pathogenic yeasts and keratinophilic
and dimorphic human pathogenic fungi known as notorious causative agents of severe endemic mycoses like histoplasmosis and
fatal cryptococcosis, especially deadly in immunocompromised individuals. This review provides an overview of bat guano
microbiota diversity and the significance of autochthonous and pathogenic taxa for humans and the environment, highlighting
better understanding in preventing emerging diseases.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4209
ISSN: 0175-7598
1432-0614
DOI: 10.1007/s00253-021-11143-y
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