Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4118
Title: Prunus spinosa L. leaf extracts: polyphenol profile and bioactivities
Authors: Veličković, Ivona 
Žižak, Željko
Rajčević, Nemanja 
IVANOV, Marija
SOKOVIĆ, Marina
Marin, Petar 
Grujić, Slavica 
Keywords: anthocyanins;antioxidant activity;antitumor activity;enzyme-inhibitory activity;leaf extracts;Prunus spinosa
Issue Date: 8-Mar-2021
Rank: M22
Publisher: University of Agricultural Sciences and Veterinary Medicine, Cluj-NapocaRomanian Academy of Agricultural and Forestry SciencesHorticulture and Forestry Society from Transylvania
Journal: Notulae Botanicae Horti Agrobotanici Cluj-Napoca
Volume: 49
Issue: 1
Start page: 12137
Abstract: 
Prunus spinosa leaf extracts in solvents of different polarity (water, ethanol and acetone), their phenol, flavonoid and anthocyanin contents and biological properties were the object of this study. The richest in phenols as well as in flavonoids was acetone extract with 181.19 mg GAE and 80.10 mg QE per gram of dry extract, respectively. Moreover, the quantity of anthocyanins obtained by HPLC analysis was also the highest in acetone sample. Examined samples possessed antioxidant properties evaluated through four in vitro assays (DPPH, ABTS, FRAP and TRC). The acetone extract was proved to be the best antioxidant among tested samples, which could be ascribed to polyphenols, especially anthocyanins. The aqueous and the ethanol extract exhibited antibacterial effects, being particularly active against B. cereus and E. cloacae. T. viride, P. funiculosum, P. ochrochloron, P. verrucosum var. cyclopium were the most susceptible among fungal microorganisms examined. Both, the aqueous and the ethanol extract expressed inhibitory activity towards enzymes linked to diabetes mellitus type II. Additionally, the ethanol extract showed significantly higher potential in inhibiting α-glucosidase than the drug used as the positive control. Furthermore, the aqueous sample revealed antitumor effects on following malignant cell lines: HeLa, K562 and MDA-MB-453. The results presented herein suggest that P. spinosa leaves should be considered as a natural source of bioactive compounds with potential application in phytopharmacy and food industry.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4118
ISSN: 1842-4309
0255-965X
DOI: 10.15835/nbha49112137
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