Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4106
Title: Proinflammatory effects of environmental cadmium boost resistance to opportunistic pathogen Aspergillus fumigatus: Implications for sustained low-level pulmonary inflammation?
Authors: Kulas, Jelena
Tucovic, Dina
Zeljkovic, Milica
Popovic, Dusanka
Popov Aleksandrov, Aleksandra
Ukropina, Mirela 
Čakić-Milošević, Maja 
Glamoclija, Jasmina
Kataranovski, Milena
Mirkov, Ivana
Keywords: Aspergillus fumigatus;Enhanced lung inflammation;Environmental health risk;Oral cadmium administration
Issue Date: 2021
Rank: M21
Project: Ministry of Education, Science and Technological Development of the Republic of Serbia (451-03-68/2020- 14/200007)
Journal: Toxicology
Abstract: 
Cadmium (Cd) is one of the most toxic environmental heavy metals to which the general population is exposed mainly via the oral route. Owing to its immunomodulatory potential, orally acquired Cd affects antimicrobial immune defense in several organs, including the lungs. While there are data concerning Cd and viral and bacterial pulmonary infections, effects on fungal infections are not studied yet. In the present study, the effect of the Cd (5 mg/L for 30 days, in drinking water, the average daily Cd intake 0.641 ± 0.089 mg/kg) on the immune response of rats to pulmonary A. fumigatus infection was examined. Data obtained showed that orally acquired cadmium does not affect the elimination of the fungus in immunocompetent rats owing to the preservation of some aspects of innate immune responses (lung leukocyte infiltration and NBT reduction) and an increase in other (increased numbers of mucus-producing goblet cells, MPO release). Cd does not affect an IFN-γ response in lung leukocytes during the infection (despite suppression of cytokine production in cells of lung-draining lymph nodes), while it stimulates IL-17 and suppresses IL-10 response to the fungus. As a result, the elimination of the fungus occurs in a milieu with the prevailing proinflammatory response in Cd-exposed animals that preserved fungal elimination from the lungs, though with more intense injury to the lung tissue. Therefore, the proinflammatory microenvironment in the lungs created by Cd that sustains inflammatory/immune response to the fungus to which humans are exposed for a lifetime, raises a concern of orally acquired Cd as a risk factor for the development of chronic low-grade pulmonary inflammation.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4106
ISSN: 0300483X
DOI: 10.1016/j.tox.2020.152634
Appears in Collections:Journal Article

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