Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4094
Title: Cadmium affects the activity of rat liver tyrosine aminotransferase and its induction by dexamethasone
Authors: Dundjerski, J.
Butorović, B.
Kipić, J.
Trajković, D.
Matić, Gordana 
Issue Date: 1996
Journal: Arch. Toxicol.
Series/Report no.: 70;390-395
Abstract: 
The effects of cadmium (Cd) administration to
intact rats on hepatic glucocorticoid receptor (GR) steroid
binding capacity and DNA-binding ability were examined
and correlated with the influence of the metal on rat liver
tyrosine aminotransferase (TAT) activity and its induction
by dexamethasone. It was found that 24 h after i.p. administration
of Cd doses ranging from 0.5 to 4 mg/kg, the GR
steroid- and DNA-binding activities were significantly
reduced in a dose-dependent manner. The same doses of
Cd also affected the basal and dexamethasone-induced
level of TAT activity, as well as the concentration of
metallothionein in rat liver. The decrease in TAT activity
and in its induction by dexamethasone observed in response
to low Cd doses was proportional to the alterations of the
GR functional properties. Higher doses of Cd, which were
more effective in reducing both the GR binding of the
hormone and to DNA, however, stimulated TAT activity
and potentiated dexamethasone induction of the enzyme.
The results led to the conclusion that Cd may alter physiological
response of rat liver cells to glucocorticoids
interfering with the GR-dependent transcriptional regulation
of the TAT gene.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4094
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