Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4069
Title: Hyperthermic stress affects the thermal modulation of glucocorticoid receptor affinity
Authors: Živadinović, D.
Vidović, S.
Matić, Gordana 
Andjus, R.K.
Issue Date: 2001
Journal: J. Thermal. Biol.
Series/Report no.: 26;575-584
Abstract: 
In vitro binding of a steroid hormone (triamcinolone acetonide) to hepatic glucocorticoid receptors was studied in
liver cytosols prepared from untreated control rats and rats sacrificed after being exposed in vivo to whole body
hyperthermia (41 or 428C). Positive temperature modulation of glucocorticoid–receptor affinity (decrease of affinity
with increasing temperature) was well expressed in all preparations. In preparations from hyperthermic rats, alterations
of a possible functional (adaptive) significance have been recorded: the amplitude of positive thermal modulation was
reduced, and its lower-temperature limit shifted towards higher temperatures. # 2001 Elsevier Science Ltd. All rights
reserved.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4069
Appears in Collections:Journal Article

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