Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4046
Title: Age, body mass index, and serum level of DHEA-S can predict glucocorticoid receptor function in women with polycystic ovary syndrome
Authors: Macut, Djuro
Vojnović Milutinović, Danijela
Božić, Ivana
Matić, Gordana 
Brkljačić, Jelena
Panidis, Dimitrios
Petakov, Milan
Spanos, Nikolaos
Bjekić, Jelica
Stanojlović, Olivera
Petrović Milinković, Anđela
Radojičić, Zoran
Damjanović, Svetozar
Issue Date: 2009
Journal: Endocrine
Series/Report no.: 37;129-134
Abstract: 
Glucocorticoid receptor (GR) transduces the glucocorticoid (GC) signal that could lead to metabolic derangements depending on the tissue responsiveness to GC. We aimed to investigate possible causative relation of the GR functional properties in peripheral blood mononuclear cells of women with polycystic ovary syndrome (PCOS), with their clinical and biochemical characteristics. Thirty women with PCOS [mean age: 26.5 ± 5.1 years, mean body mass index (BMI) 24.5 ± 5 kg/m(2)], and thirty respective controls were analyzed for the number of GR sites per cell (B (max)), apparent equilibrium dissociation constant (K (d)), and binding potency (GR potency). A strong association between B (max) and K (d) (r = 0.70, P < 0.0001), and GR potency with age (r = 0.49, P = 0.009) was observed in PCOS women. The multiple regression analyses within the PCOS group revealed that independent predictors for K (d) were BMI, total cholesterol, and dehydroepiandrosterone-sulfate (DHEA-S) (r = 0.58, P = 0.038), while for GR potency (r = 0.687, P = 0.013) were age, BMI, DHEA-S, and basal cortisol concentration. The results suggest that PCOS pathophysiology may be related to alterations of a cross stalk between glucocorticoid signaling, age, and metabolic parameters. These findings should be further explored in studies on the role of GR in PCOS-related metabolic derangements.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4046
ISSN: 1355-008X
1559-0100
DOI: 10.1007/s12020-009-9277-9
Appears in Collections:Journal Article

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