Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4023
Title: Leptin and glucocorticoid signaling pathways in the hypothalamus of female and male fructose-fed rats
Authors: Vojnovic-Milutinovic, Danijela
Nikolic, Marina
Dinic, Jovana
Djordjevic, Ana
Velickovic, Natasa
Elakovic, Ivana
Matić, Gordana 
Nestorov, Jelena
Issue Date: 2014
Journal: Archives of Biological Sciences
Series/Report no.: 66;829-839
Abstract: 
Alterations in leptin and glucocorticoid signaling pathways in the hypothalamus of male and female rats
subjected to a fructose-enriched diet were studied. The level of expression of the key components of the leptin signaling
pathway (neuropeptide Y /NPY/ and suppressor of cytokine signaling 3 /SOCS3/), and the glucocorticoid signaling
pathway (glucocorticoid receptor /GR/, 11β-hydroxysteroid dehydrogenase type 1 /11βHSD1/ and hexose-6-phosphate
dehydrogenase /H6PDH/) did not differ between fructose-fed rats and control animals of both genders. However, in females,
a fructose-enriched diet provoked increases in the adiposity index, plasma leptin and triglyceride concentrations,
and displayed a tendency to decrease the leptin receptor (ObRb) protein and mRNA levels. In male rats, the fructose diet
caused elevations in plasma non-esterified fatty acids and triglycerides, as well as in both plasma and hypothalamic leptin
concentrations. Our results suggest that a fructose-enriched diet can induce hyperleptinemia in both female and male rats,
but with a more pronounced effect on hypothalamic leptin sensitivity in females, probably contributing to the observed
development of visceral adiposity.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4023
ISSN: 0354-4664
1821-4339
DOI: 10.2298/ABS1402829M
Appears in Collections:Journal Article

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