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https://biore.bio.bg.ac.rs/handle/123456789/4023
Title: | Leptin and glucocorticoid signaling pathways in the hypothalamus of female and male fructose-fed rats | Authors: | Vojnovic-Milutinovic, Danijela Nikolic, Marina Dinic, Jovana Djordjevic, Ana Velickovic, Natasa Elakovic, Ivana Matić, Gordana Nestorov, Jelena |
Issue Date: | 2014 | Journal: | Archives of Biological Sciences | Series/Report no.: | 66;829-839 | Abstract: | Alterations in leptin and glucocorticoid signaling pathways in the hypothalamus of male and female rats subjected to a fructose-enriched diet were studied. The level of expression of the key components of the leptin signaling pathway (neuropeptide Y /NPY/ and suppressor of cytokine signaling 3 /SOCS3/), and the glucocorticoid signaling pathway (glucocorticoid receptor /GR/, 11β-hydroxysteroid dehydrogenase type 1 /11βHSD1/ and hexose-6-phosphate dehydrogenase /H6PDH/) did not differ between fructose-fed rats and control animals of both genders. However, in females, a fructose-enriched diet provoked increases in the adiposity index, plasma leptin and triglyceride concentrations, and displayed a tendency to decrease the leptin receptor (ObRb) protein and mRNA levels. In male rats, the fructose diet caused elevations in plasma non-esterified fatty acids and triglycerides, as well as in both plasma and hypothalamic leptin concentrations. Our results suggest that a fructose-enriched diet can induce hyperleptinemia in both female and male rats, but with a more pronounced effect on hypothalamic leptin sensitivity in females, probably contributing to the observed development of visceral adiposity. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/4023 | ISSN: | 0354-4664 1821-4339 |
DOI: | 10.2298/ABS1402829M |
Appears in Collections: | Journal Article |
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