Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/4023
DC Field | Value | Language |
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dc.contributor.author | Vojnovic-Milutinovic, Danijela | en_US |
dc.contributor.author | Nikolic, Marina | en_US |
dc.contributor.author | Dinic, Jovana | en_US |
dc.contributor.author | Djordjevic, Ana | en_US |
dc.contributor.author | Velickovic, Natasa | en_US |
dc.contributor.author | Elakovic, Ivana | en_US |
dc.contributor.author | Matić, Gordana | en_US |
dc.contributor.author | Nestorov, Jelena | en_US |
dc.date.accessioned | 2021-04-16T15:43:06Z | - |
dc.date.available | 2021-04-16T15:43:06Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0354-4664 | - |
dc.identifier.issn | 1821-4339 | - |
dc.identifier.uri | https://biore.bio.bg.ac.rs/handle/123456789/4023 | - |
dc.description.abstract | Alterations in leptin and glucocorticoid signaling pathways in the hypothalamus of male and female rats subjected to a fructose-enriched diet were studied. The level of expression of the key components of the leptin signaling pathway (neuropeptide Y /NPY/ and suppressor of cytokine signaling 3 /SOCS3/), and the glucocorticoid signaling pathway (glucocorticoid receptor /GR/, 11β-hydroxysteroid dehydrogenase type 1 /11βHSD1/ and hexose-6-phosphate dehydrogenase /H6PDH/) did not differ between fructose-fed rats and control animals of both genders. However, in females, a fructose-enriched diet provoked increases in the adiposity index, plasma leptin and triglyceride concentrations, and displayed a tendency to decrease the leptin receptor (ObRb) protein and mRNA levels. In male rats, the fructose diet caused elevations in plasma non-esterified fatty acids and triglycerides, as well as in both plasma and hypothalamic leptin concentrations. Our results suggest that a fructose-enriched diet can induce hyperleptinemia in both female and male rats, but with a more pronounced effect on hypothalamic leptin sensitivity in females, probably contributing to the observed development of visceral adiposity. | en_US |
dc.relation.ispartof | Archives of Biological Sciences | en_US |
dc.relation.ispartofseries | 66;829-839 | - |
dc.title | Leptin and glucocorticoid signaling pathways in the hypothalamus of female and male fructose-fed rats | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.2298/ABS1402829M | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | restricted | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Chair of Biochemistry and Molecular Biology | - |
crisitem.author.orcid | 0000-0002-0142-1056 | - |
Appears in Collections: | Journal Article |
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File | Description | Size | Format | Existing users please |
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Vojnovic_Milutinovic-ArchBiolSci-2014.pdf | 863.25 kB | Adobe PDF | Request a copy |
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