Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4023
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dc.contributor.authorVojnovic-Milutinovic, Danijelaen_US
dc.contributor.authorNikolic, Marinaen_US
dc.contributor.authorDinic, Jovanaen_US
dc.contributor.authorDjordjevic, Anaen_US
dc.contributor.authorVelickovic, Natasaen_US
dc.contributor.authorElakovic, Ivanaen_US
dc.contributor.authorMatić, Gordanaen_US
dc.contributor.authorNestorov, Jelenaen_US
dc.date.accessioned2021-04-16T15:43:06Z-
dc.date.available2021-04-16T15:43:06Z-
dc.date.issued2014-
dc.identifier.issn0354-4664-
dc.identifier.issn1821-4339-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/4023-
dc.description.abstractAlterations in leptin and glucocorticoid signaling pathways in the hypothalamus of male and female rats subjected to a fructose-enriched diet were studied. The level of expression of the key components of the leptin signaling pathway (neuropeptide Y /NPY/ and suppressor of cytokine signaling 3 /SOCS3/), and the glucocorticoid signaling pathway (glucocorticoid receptor /GR/, 11β-hydroxysteroid dehydrogenase type 1 /11βHSD1/ and hexose-6-phosphate dehydrogenase /H6PDH/) did not differ between fructose-fed rats and control animals of both genders. However, in females, a fructose-enriched diet provoked increases in the adiposity index, plasma leptin and triglyceride concentrations, and displayed a tendency to decrease the leptin receptor (ObRb) protein and mRNA levels. In male rats, the fructose diet caused elevations in plasma non-esterified fatty acids and triglycerides, as well as in both plasma and hypothalamic leptin concentrations. Our results suggest that a fructose-enriched diet can induce hyperleptinemia in both female and male rats, but with a more pronounced effect on hypothalamic leptin sensitivity in females, probably contributing to the observed development of visceral adiposity.en_US
dc.relation.ispartofArchives of Biological Sciencesen_US
dc.relation.ispartofseries66;829-839-
dc.titleLeptin and glucocorticoid signaling pathways in the hypothalamus of female and male fructose-fed ratsen_US
dc.typeArticleen_US
dc.identifier.doi10.2298/ABS1402829M-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Biochemistry and Molecular Biology-
crisitem.author.orcid0000-0002-0142-1056-
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