Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4016
Title: Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD
Authors: Matić, Gordana 
Milutinović, Danijela Vojnović
Nestorov, Jelena
Elaković, Ivana
Jovanović, Sanja Manitašević
Elzaedi, Younis Mouftah
Perišić, Tatjana
Dunđerski, Jadranka
Damjanović, Svetozar
Knežević, Goran
Špirić, Željko
Vermetten, Eric
Savić, Danka
Keywords: Glucocorticoid receptor;Hsp70;Hsp90;Mineralocorticoid receptor;PTSD;War trauma
Issue Date: 2014
Journal: Psychiatry Research
Series/Report no.: 215;379-385
Abstract: 
Alterations in the number and functional status of mineralocorticoid (MR) and glucocorticoid receptors (GR) may contribute to vulnerability to posttraumatic stress disorder (PTSD). Corticosteroid receptors are chaperoned by heat shock proteins Hsp90 and Hsp70. We examined relations between corticosteroid receptor and heat shock protein expression levels, and related them with war trauma exposure, PTSD and resilience to PTSD. Relative levels of MR, Hsp90 and Hsp70 were determined by immunoblotting in lymphocytes from war trauma-exposed men with current PTSD (current PTSD group, n=113), with life-time PTSD (life-time PTSD group, n=61) and without PTSD (trauma control group, n=88), and from non-traumatized healthy controls (healthy control group, n=85). Between-group differences in MR, Hsp90 and Hsp70 levels and in MR/GR ratio were not observed. The level of MR was correlated with both Hsp90 and Hsp70 levels in trauma control and healthy control groups. On the other hand, GR level was correlated only with Hsp90 level, and this correlation was evident in current PTSD and trauma control groups. In conclusion, PTSD and exposure to trauma are not related to changes in lymphocyte MR, Hsp90 or Hsp70 levels, but may be associated with disturbances in corticosteroid receptors interaction with heat shock proteins.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4016
ISSN: 0165-1781
DOI: 10.1016/j.psychres.2013.11.022
Appears in Collections:Journal Article

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