Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/3999
Title: Possible involvement of glucocorticoids in 5α-dihydrotestosterone-induced PCOS-like metabolic disturbances in the rat visceral adipose tissue
Authors: Nikolić, Marina
Macut, Djuro
Djordjevic, Ana
Veličković, Nataša
Nestorović, Nataša
Bursać, Biljana
Antić, Ivana Božić
Macut, Jelica Bjekić
Matić, Gordana 
Vojnović Milutinović, Danijela
Keywords: 5α-dihydrotestosterone;Glucocorticoids;Lipogenesis;PCOS;Visceral adipose tissue
Issue Date: 2015
Journal: Molecular and Cellular Endocrinology
Series/Report no.: 399;22-31
Abstract: 
Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder characterized by hyperandrogenism, ovulatory dysfunction, visceral obesity and insulin resistance. We hypothesized that changes in glucocorticoid metabolism and signaling in the visceral adipose tissue may contribute to disturbances of lipid metabolism in the rat model of PCOS obtained by 5α-dihydrotestosterone (DHT) treatment of prepubertal female Wistar rats. The results confirmed that DHT treatment caused anovulation, obesity and dyslipidemia. Enhanced glucocorticoid prereceptor metabolism, assessed by elevated intracellular corticosterone and increased 11 beta-hydroxysteroid dehydrogenase type 1 mRNA and protein levels, was accompanied by glucocorticoid receptor (GR) nuclear accumulation. In concert with the increased expression of GR-regulated prolipogenic genes (lipin-1, sterol regulatory element binding protein 1, fatty acid synthase, phosphoenolpyruvate carboxykinase), histological analyses revealed hypertrophic adipocytes. The results suggest that glucocorticoids influence lipid metabolism in the visceral adipose tissue in the way that may contribute to pathogenesis of metabolic disturbances associated with PCOS.
URI: https://biore.bio.bg.ac.rs/handle/123456789/3999
ISSN: 0303-7207
DOI: 10.1016/j.mce.2014.08.013
Appears in Collections:Journal Article

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