Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/3693
Title: In vivo Cell Tracking Using Non-invasive Imaging of Iron Oxide-Based Particles with Particular Relevance for Stem Cell-Based Treatments of Neurological and Cardiac Disease
Authors: Glover, Joel C.
Aswendt, Markus
Boulland, Jean-Luc
Lojk, Jasna
Stamenković, Stefan 
Andjus, Pavle 
Fiori, Fabrizio
Hoehn, Mathias
Mitrecic, Dinko
Pavlin, Mojca
Cavalli, Stefano
Frati, Caterina
Quaini, Federico
Keywords: Cardiomyocytes;Iron oxide;MION;MPI;MPIO;MRI;Micro-CT;Neural progenitor cells;SPIO;Stem cell;USPIO
Issue Date: Dec-2019
Rank: M21
Citation: Glover JC, Aswendt M, Boulland JL, Lojk J, Stamenković S, Andjus P, Fiori F, Hoehn M, Mitrecic D, Pavlin M, Cavalli S, Frati C, Quaini F; EU COST Action 16122 (BIONECA). In vivo Cell Tracking Using Non-invasive Imaging of Iron Oxide-Based Particles with Particular Relevance for Stem Cell-Based Treatments of Neurological and Cardiac Disease. Mol Imaging Biol. 2020 Dec;22(6):1469-1488. doi: 10.1007/s11307-019-01440-4. PMID: 31802361.
Journal: Molecular Imaging and Biology
Abstract: 
Stem cell-based therapeutics is a rapidly developing field associated with a number of clinical challenges. One such challenge lies in the implementation of methods to track stem cells and stem cell-derived cells in experimental animal models and in the living patient. Here, we provide an overview of cell tracking in the context of cardiac and neurological disease, focusing on the use of iron oxide-based particles (IOPs) visualized in vivo using magnetic resonance imaging (MRI). We discuss the types of IOPs available for such tracking, their advantages and limitations, approaches for labeling cells with IOPs, biological interactions and effects of IOPs at the molecular and cellular levels, and MRI-based and associated approaches for in vivo and histological visualization. We conclude with reviews of the literature on IOP-based cell tracking in cardiac and neurological disease, covering both preclinical and clinical studies.
URI: https://biore.bio.bg.ac.rs/handle/123456789/3693
ISSN: 1536-1632
1860-2002
DOI: 10.1007/s11307-019-01440-4
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