Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/3679
Title: Gray-Level Co-Occurrence Matrix Analysis of Granule Neurons of the Hippocampal Dentate Gyrus Following Cortical Injury
Authors: Pantic, Igor
Jeremic, Rada
Dacic, Sanja 
Pekovic, Sanja
Pantic, Senka
Djelic, Marina
Vitic, Zagorka
Brkic, Predrag
Brodski, Claude
Keywords: dentate gyrus;gray-level co-occurrence matrix analysis;hippocampus;sensorimotor cortex ablation;texture;traumatic brain injury
Issue Date: Feb-2020
Rank: M21
Citation: Pantic I, Jeremic R, Dacic S, Pekovic S, Pantic S, Djelic M, Vitic Z, Brkic P, Brodski C. Gray-Level Co-Occurrence Matrix Analysis of Granule Neurons of the Hippocampal Dentate Gyrus Following Cortical Injury. Microsc Microanal. 2020 Feb;26(1):166-172. doi: 10.1017/S143192762000001X. PMID: 31948501.
Journal: Microscopy and Microanalysis
Abstract: 
Traumatic brain injury (TBI) is a main cause of death and disabilities in young adults. Although learning and memory impairments are a major clinical manifestation of TBI, the consequences of TBI on the hippocampus are still not well understood. In particular, how lesions to the sensorimotor cortex damage the hippocampus, to which it is not directly connected, is still elusive. Here, we study the effects of sensorimotor cortex ablation (SCA) on the hippocampal dentate gyrus, by applying a highly sensitive gray-level co-occurrence matrix (GLCM) analysis. Using GLCM analysis of granule neurons, we discovered, in our TBI paradigm, subtle changes in granule cell (GC) morphology, including textual uniformity, contrast, and variance, which is not detected by conventional microscopy. We conclude that sensorimotor cortex trauma leads to specific changes in the hippocampus that advance our understanding of the cellular underpinnings of cognitive impairments in TBI. Moreover, we identified GLCM analysis as a highly sensitive method to detect subtle changes in the GC layers that is expected to significantly improve further studies investigating the impact of TBI on hippocampal neuropathology.
URI: https://biore.bio.bg.ac.rs/handle/123456789/3679
ISSN: 1431-9276
1435-8115
DOI: 10.1017/S143192762000001X
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