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Title: | Vortioxetine reduces pain hypersensitivity and associated depression-like behavior in mice with oxaliplatin-induced neuropathy | Authors: | Micov, Ana M. Tomić, Maja A. Todorović, Marija B. Vuković, Milja J. Pecikoza, Uroš B. Jasnić, Nebojša Đorđević, Jelena Stepanović-Petrović, Radica M. |
Keywords: | Vortioxetine;Oxaliplatin-induced neuropathy;Mechanical/cold allodynia;Depression-like behavior;Brainstem;5-HT;noradrenaline | Issue Date: | 20-Dec-2020 | Rank: | M21 | Journal: | Progress in Neuro-Psychopharmacology and Biological Psychiatry | Abstract: | Chronic pain and depression commonly occur together so dual-acting agents might be particularly useful. The population of patients with chemotherapy-induced neuropathy is increasing in parallel with the increase of population of cancer survivors and there is a compelling need for satisfactory treatment of symptoms of neuropathy and concomitant depression. We examined the effects of vortioxetine, a novel antidepressant with unique mechanism of action, on pain hypersensitivity and depression-like behavior in oxaliplatin-induced neuropathy model in mice (OIPN). Vortioxetine (1–10 mg/kg, p.o.) significantly and dose-dependently reduced mechanical allodynia in von Frey test and cold allodynia in acetone test in OIPN mice, in both repeated prophylactic and acute therapeutic treatment regimens. It also reduced depression-like behavior in the forced swimming test in OIPN mice, in both treatment paradigms. Its antiallodynic and antidepressive-like effects were comparable to those exerted by duloxetine (1–15 mg/kg, p.o.). The antiallodynic and antidepressive-like effects of repeatedly administered vortioxetine might be related to the increased content of 5-hydroxytryptamine (5-HT) and noradrenaline (NA), detected in the brainstem of treated OIPN mice. These results indicate that vortioxetine could be potentially useful in prevention and treatment of chemotherapy-induced neuropathy, for the relief of pain and concomitant depressive symptoms. It should be further tested to this regard in clinical settings. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/3659 | ISSN: | 0278-5846 | DOI: | 10.1016/j.pnpbp.2020.109975 |
Appears in Collections: | Journal Article |
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