Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/345
Title: | MicroRNA meta-signature of oral cancer: evidence from a meta-analysis | Authors: | Zeljić, Katarina Jovanovic, Ivan Jovanovic, Jasmina Magic, Zvonko Stankovic, Aleksandra Supic, Gordana |
Keywords: | Enrichment analysis;meta-analysis;meta-signature;miRNA;oral cancer | Issue Date: | 2-Jan-2018 | Rank: | M21 | Journal: | Upsala Journal of Medical Sciences | Abstract: | © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Aim: It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. Material and methods: Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis. Results: Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue. Eleven miRNAs were consistently up-regulated in three or more studies (miR-21-5p, miR-31-5p, miR-135b-5p, miR-31-3p, miR-93-5p, miR-34b-5p, miR-424-5p, miR-18a-5p, miR-455-3p, miR-450a-5p, miR-21-3p), and nine were down-regulated (miR-139-5p, miR-30a-3p, miR-376c-3p, miR-885-5p, miR-375, miR-486-5p, miR-411-5p, miR-133a-3p, miR-30a-5p). The meta-signature of identified miRNAs was functionally characterized by KEGG enrichment analysis. Twenty-four KEGG pathways were significantly enriched, and TGF-beta signaling was the most enriched signaling pathway. The highest number of meta-signature miRNAs was involved in the sphingolipid signaling pathway. Natural killer cell-mediated cytotoxicity was the pathway with most genes regulated by identified miRNAs. The rest of the enriched pathways in our miRNA list describe different malignancies and signaling. Conclusions: The identified miRNA meta-signature might be considered as a potential battery of biomarkers when distinguishing oral cancer tissue from normal, non-cancerous tissue. Further mechanistic studies are warranted in order to confirm and fully elucidate the role of deregulated miRNAs in oral cancer. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/345 | ISSN: | 0300-9734 | DOI: | 10.1080/03009734.2018.1439551 |
Appears in Collections: | Journal Article |
Show full item record
SCOPUSTM
Citations
50
checked on Nov 1, 2024
Page view(s)
3
checked on Nov 5, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.