Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/345
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dc.contributor.authorZeljić, Katarinaen_US
dc.contributor.authorJovanovic, Ivanen_US
dc.contributor.authorJovanovic, Jasminaen_US
dc.contributor.authorMagic, Zvonkoen_US
dc.contributor.authorStankovic, Aleksandraen_US
dc.contributor.authorSupic, Gordanaen_US
dc.date.accessioned2019-07-01T11:32:23Z-
dc.date.available2019-07-01T11:32:23Z-
dc.date.issued2018-01-02-
dc.identifier.issn0300-9734-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/345-
dc.description.abstract© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Aim: It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. Material and methods: Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis. Results: Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue. Eleven miRNAs were consistently up-regulated in three or more studies (miR-21-5p, miR-31-5p, miR-135b-5p, miR-31-3p, miR-93-5p, miR-34b-5p, miR-424-5p, miR-18a-5p, miR-455-3p, miR-450a-5p, miR-21-3p), and nine were down-regulated (miR-139-5p, miR-30a-3p, miR-376c-3p, miR-885-5p, miR-375, miR-486-5p, miR-411-5p, miR-133a-3p, miR-30a-5p). The meta-signature of identified miRNAs was functionally characterized by KEGG enrichment analysis. Twenty-four KEGG pathways were significantly enriched, and TGF-beta signaling was the most enriched signaling pathway. The highest number of meta-signature miRNAs was involved in the sphingolipid signaling pathway. Natural killer cell-mediated cytotoxicity was the pathway with most genes regulated by identified miRNAs. The rest of the enriched pathways in our miRNA list describe different malignancies and signaling. Conclusions: The identified miRNA meta-signature might be considered as a potential battery of biomarkers when distinguishing oral cancer tissue from normal, non-cancerous tissue. Further mechanistic studies are warranted in order to confirm and fully elucidate the role of deregulated miRNAs in oral cancer.en_US
dc.language.isoenen_US
dc.relation.ispartofUpsala Journal of Medical Sciencesen_US
dc.subjectEnrichment analysisen_US
dc.subjectmeta-analysisen_US
dc.subjectmeta-signatureen_US
dc.subjectmiRNAen_US
dc.subjectoral canceren_US
dc.titleMicroRNA meta-signature of oral cancer: evidence from a meta-analysisen_US
dc.typeArticleen_US
dc.identifier.doi10.1080/03009734.2018.1439551-
dc.identifier.pmid29482431-
dc.identifier.scopus2-s2.0-85042931110-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85042931110-
dc.description.rankM21-
dc.description.impact3.411-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Genetics and Evolution-
crisitem.author.orcid0000-0002-3906-7785-
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