Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/345
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zeljić, Katarina | en_US |
dc.contributor.author | Jovanovic, Ivan | en_US |
dc.contributor.author | Jovanovic, Jasmina | en_US |
dc.contributor.author | Magic, Zvonko | en_US |
dc.contributor.author | Stankovic, Aleksandra | en_US |
dc.contributor.author | Supic, Gordana | en_US |
dc.date.accessioned | 2019-07-01T11:32:23Z | - |
dc.date.available | 2019-07-01T11:32:23Z | - |
dc.date.issued | 2018-01-02 | - |
dc.identifier.issn | 0300-9734 | - |
dc.identifier.uri | https://biore.bio.bg.ac.rs/handle/123456789/345 | - |
dc.description.abstract | © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Aim: It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. Material and methods: Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis. Results: Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue. Eleven miRNAs were consistently up-regulated in three or more studies (miR-21-5p, miR-31-5p, miR-135b-5p, miR-31-3p, miR-93-5p, miR-34b-5p, miR-424-5p, miR-18a-5p, miR-455-3p, miR-450a-5p, miR-21-3p), and nine were down-regulated (miR-139-5p, miR-30a-3p, miR-376c-3p, miR-885-5p, miR-375, miR-486-5p, miR-411-5p, miR-133a-3p, miR-30a-5p). The meta-signature of identified miRNAs was functionally characterized by KEGG enrichment analysis. Twenty-four KEGG pathways were significantly enriched, and TGF-beta signaling was the most enriched signaling pathway. The highest number of meta-signature miRNAs was involved in the sphingolipid signaling pathway. Natural killer cell-mediated cytotoxicity was the pathway with most genes regulated by identified miRNAs. The rest of the enriched pathways in our miRNA list describe different malignancies and signaling. Conclusions: The identified miRNA meta-signature might be considered as a potential battery of biomarkers when distinguishing oral cancer tissue from normal, non-cancerous tissue. Further mechanistic studies are warranted in order to confirm and fully elucidate the role of deregulated miRNAs in oral cancer. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Upsala Journal of Medical Sciences | en_US |
dc.subject | Enrichment analysis | en_US |
dc.subject | meta-analysis | en_US |
dc.subject | meta-signature | en_US |
dc.subject | miRNA | en_US |
dc.subject | oral cancer | en_US |
dc.title | MicroRNA meta-signature of oral cancer: evidence from a meta-analysis | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1080/03009734.2018.1439551 | - |
dc.identifier.pmid | 29482431 | - |
dc.identifier.scopus | 2-s2.0-85042931110 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85042931110 | - |
dc.description.rank | M21 | - |
dc.description.impact | 3.411 | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Chair of Genetics and Evolution | - |
crisitem.author.orcid | 0000-0002-3906-7785 | - |
Appears in Collections: | Journal Article |
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