Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/342
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dc.contributor.authorVujović, Predragen_US
dc.contributor.authorĐorđević, Jelenaen_US
dc.contributor.authorLakić, Ivaen_US
dc.contributor.authorJasnić, Nebojšaen_US
dc.contributor.authorĐurašević, Sinišaen_US
dc.contributor.authorLaketa, Danijelaen_US
dc.contributor.authorCvijić, Gordanaen_US
dc.date.accessioned2019-07-01T11:26:40Z-
dc.date.available2019-07-01T11:26:40Z-
dc.date.issued2010-09-10-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/342-
dc.description.abstractLeptin has long been recognised as the potent appetite mediator and body mass regulator. We compared the effects of various fasting periods on leptin concentration in rat serum, pituitary and hypothalamus. The animals were food deprived for 6 h, 12 h, 24 h, 48 h and 72 h (n=6). Each of the fasted groups was sacrificed simultaneously with the group of ad libitum fed animals which (n=6). Serum leptin in starved animals was either lower than the control level (6 h, 12 h) or showed no significant change to the controls (24 h, 48 h, 72 h). Pituitary leptin was increased in the two groups which were subjected to shortest fasting periods (6 h, 12 h) and the group with the longest fasting period (72 h). Hypothalamic leptin was first higher in fasted animlas (6 h), then reached (12 h) and finaly declined beneath the control level (24 h, 48 h, 72 h). The corresponding metabolic parametars, such as blood glucose, insulin, urea, free fatty acids and corticosterone levels were also measured to help estimate which of the three fasting phases was ongoing at the time of decapitation. Collectively, our results suggest that the changes in leptin concentrations display tissue specific patterns in different phases of fasting implying that leptin also plays roles other than that of the appetite regulator.en_US
dc.language.isoenen_US
dc.subjectFastingen_US
dc.subjectLeptinen_US
dc.subjectHypothalamusen_US
dc.titleEffects of various fasting periods on serum, pituitary and hypothalamic leptin levels in ratsen_US
dc.typeConference Paperen_US
dc.relation.conference“One hundred years of Ivan Djaja’s (Jean Giaja) Belgrade school of physiology”en_US
dc.date.updated2023-10-14-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeConference Paper-
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.deptChair of General Physiology and Biophysics-
crisitem.author.orcid0000-0002-9444-4758-
crisitem.author.orcid0000-0002-6510-1027-
crisitem.author.orcid0000-0001-8894-7300-
crisitem.author.orcid0000-0003-0333-333X-
crisitem.author.orcid0000-0003-4406-8376-
crisitem.author.orcid0000-0002-6563-8924-
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